'''This is a landscape report on the Ureteral stent market, including key company profiles, products, patents and relevant clinical trailstrials.
'''
=Patents=
==Patent Search Strategy==
[[Image:Patent Search Strategy.jpg|700px]]
'''Dashboard Link'''<br>
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|'''[httphttps://clientwww.dolcera.com/auth/dashboard/dashboard.htmlphp?workfile_id=1008 Ureteral Stent - Dashboard] '''
|width="100"|[[Image:dashboard_thumb.png|center|100px|]]
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= Clinical Trials =
==New trials ==
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=Products=Timeline Visualization ==[[Image:Timeline.jpg]]
[[Media:Ureteral_Stents_Timeline dw.xls|Ureteral Stent Timeline]]
=Products=
The FDA classifies a ureteric stent as follows:
* TITLE 21 - FOOD AND DRUGS
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=Patent-Product-Clinical Trial Mapping=
* To access the Dashboard you have to signup. You can do so by clicking [https://www.dolcera.com/auth/index.php/login '''here''']
*''Use the mouse(click and drag/scroll up or down/click on nodes) to explore nodes in the detailed taxonomy''
*''Click on the red arrow adjacent to the node name to view the content for that particular node in the dashboard''
*''Click on the "+" sign to zoom the mindmap and "-" sign to shrink the mindmap''
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|<mm>[[ureteral_stent_mapping1.mm|flash|Ureteral Stent mindmap|600pt]]</mm>
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=Product to Clinical Trial Mapping+
= Product to Clinical Trial Mapping=
= Product to Patent Mapping =
[[Image:Product_Patent_Mapping_Screen_Shot.png|1000px|centre|thumb|'''Screenshot for the product to patent mapping(Bard and Boston)''']]
* Click [[Media:Product_Patent_Mapping_Bard_Boston.xls|'''here Products from Boston Scientific and C R Bard ''']]to download the excel file.* == Mapped Patent vs Not Mapped Patents==
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|[[Image:CRB_Pat.png|center|500px|thumb|'''C R Bard''']]
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=InsightsPatent-Product-Clinical Trial Mapping=
* To access the Dashboard you have to signup. You can do so by clicking [https://www.dolcera.com/auth/index.php/login '''here''']*''Use the mouse(click and drag/scroll up or down/click on nodes) to explore nodes in the detailed taxonomy''*''Click on the red arrow adjacent to the node name to view the content for that particular node in the dashboard'' *''Click on the "+" sign to zoom the mindmap and "-" sign to shrink the mindmap''{|border="2" cellspacing=Boston Scientific"0" cellpadding="4" width="100%"
===Products===* They have '''8 ureteral stents''' in their portfolio* Boston's ureteral stent portfolio have some common features such as:#|<mm>[[ureteral_stent_mapping1.mm|flash|Ureteral Stent '''material''' consisting of '''Percuflex'''- a Biocompatible Polymer Material#The '''coating''' on the stent may be a '''Hydroplus''' coating#Most of the stents are designed to have an '''indwelling time''' of '''365 days'''#Pigtailed shaped ureteral stentmindmap|600pt]]</mm>
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=Insights=
{|border="2" cellspacing="0" cellpadding=Clinical trials"4" width="100%"|bgcolor ="#538ED5"|<font size ="4">''' '''</font>* |bgcolor = "#538ED5"|<font size = "4">''' '''</font>|bgcolor = "#538ED5"|<font size = "4">'''Boston scientific is conducting clinical Scientific'''trials</font>|bgcolor = "#538ED5"|<font size = "4">''' for C R BARD'''Truimph Ureteral stent</font>|-|align = "center" bgcolor = "#538ED5" rowspan = "4"|''' which is a ureteral Products'''stent|''' loaded with Portfolio'''Triclosan|8 Products|6 Products|-|''' (used as an antimicrobial agent).The trials are currently in Material'''|Percuflex - Biocompatible Polymer|Silicone|-|'''Coating'''|Hydroplus|Licensed from pHreecoat|-|'''Shape'''|Pigtailed and More|Figure 4 and more|-|align = "center" bgcolor = "#538ED5"|'''Clinical <br>Trials'''|'''Current Trials'''|Truimph Ureteral stent - Loaded with Triclosan <br>Currently in Phase II(Canada)|None|-|align = "center" bgcolor = "#538ED5" rowspan = "3"|''' Patents'''|'''Coating'''|Therapeutic / Medicinal coatings <br>Magnetic nano particles for MRI Imaging <br>Lubricious coatings helping easy insertion|Therapeutic coatings|-|'''Structure'''|Multiple channels filled with therapeutic agent<br>Multiple collapsible segments preventing fluid passing<br>Renal coil with wick to prevent reflux <br>Stent with beads on its surface <br>Stent with reservoir indicating its release <br>with change in color of urine<br>Expandable and collapsible stent<br>Stents with degradable barbs|Expandable stents for reducing discomfort|-|'''canadaMaterial'''(NCT00250406).|Elastically deformable stents<br>Biodegradable polymer based stents<br>Porous polymer for long term implantation<br>Stent with variable hardness|Biodegradable polymers<br>Shape memory alloys<br>General polymer based|-|}
===Patents===
*The unmapped patents are analysed based on the following parameters'''1.Coating on stents:''' Boston scientific has patents on Therapeutic/ medicinal coatings on stents which releases into the vascular region. Magnetic nanoparticles which helps in imaging the ureteral stent using MRI. Lubricious coatings which help in easy insertion of the stent== Inference ==
'''{|border="2.Structure of stent:''' Boston scientific has patents on various structures of stent . For eg: Multiple channels(Depressions) along the length of stent filled with therapeutic agent,Multiple segments on the distal side of stent which is collapsible to prevent fluid from passing from the bladder to the kidney, Stent with a renal coil with wick portion to prevent reflux of urine,Stent with beads on its surface which is of figure 8 shape having therapeutic agents, Stent with reservoir indicating its release with change in color of urine,Stents with degradable barbs,Expandable and collapsible stent to reduce patient discomfort '''3.Materials used for stent:'''Boston scientific has patents on various materials used for stent. For eg.Elastically deformable stents(polysaccharide-based hydrogels), Biodegradable polymer based stents, Porous polymer for long term implantation( poly(styrene) blocks and polyisobutylene blocks),Stent with variable hardness (ethylene vinyl acetate and hydroxypropylcellulose) " cellspacing="0" cellpadding=C.R.Bard="4" width="82%" |bgcolor ="#538ED5"|<font size ==Products===* They have "4">'''6 productsBoston Scientific''' in their ureteral stent portfolio* C.R Bard ureteral stent portfolio have some common features such as:</font>|bgcolor = "#Most of the stent has '''Silicone''' as their '''main material'''#They have stent with '''various''' '''designs''' and shapes eg Figure 538ED5"|<font size = "4 ureteral stent#Some of the stent have '''coatings''' which is '''liscensed''' from third party eg.">'''pHreecoatC R BARD'''"</font>|-|Relatively late entrant with patents filed post mid 90s|Early mover with patents filed in mid 80s===Clinical trials===|-There are '''no trials currently''' conducted by C.R.Bard.|Increased patent activity since 2000|Patent activity never gained traction===Patents===|-C R Bard is '''not very active''' in filing |Large number of patents with very '''few''' yet to be "productized"|Few patents '''filed after 2000'''.yet to be "productized"|-*The unmapped patents are analysed based on the following parameters|Some products undergoing clinical trails|No products undergoing clinical trails'''1.Coating on stent:'''They have a couple |-|Diverse range of patents related to therapeutic coatigs on stent surfaceproducts with variation in material <br>and structure|Small product portfolio'''2.Structure of stent:'''C R. Bard patents are related |-|Seem to expandable be strengthening they market position|Seem to be moving focus away from Ureteral stents for reducing patent discomfortmarket|-'''3.Material used on stent:''' Recent patents focuses on Biodegrable polymers, Shape memory alloys or general polymer based stent|}
=Key FindingsCompetitive Landscape =
==Major Players==
*Boston Scientific Limited, Abbott, Medtronic and Cook Inc. are the major players in ureteral stent research field.
[[Image:Major playersnew.jpg|thumb|center|1000px|Major Players]]
==Key Patents==
*The key patents in the field are held by Cook Incorporated, Interventional Thermodynamics, Abbott laboratories and Boston Scientific Corp.
[[Image:Key patent2.png|thumb|center|1100px|Key Patents]]
==IP Activity==
*Patenting activity has been high growth rate during the period 2001 to 2005 with a peak no. of patents in year 2005, followed by saturation during the period 2006 to 2008 and after that a gradual declination upto year 2010 in the ureteral stent research area.
[[Image:IPactivity3.png|thumb|center|1000px|year wise IP activityover the years]] ==Geographical Activity==*USA, Europe and Germany are very active in ureteral stent research. [[Image:Geodistribution5.png|thumb|center|600px|Geographical Activity]]
=Competitor Analysis=Sales ==
Total Sales in 2010 - 4.04 Billion USD
All figures in USD million [[image:stentshare.jpg]] ====Boston Scientific==== [https://dolcera.net/teamwiki_prod/index.php/Boston_Scientific_-_Company_Profile Company profile] [http://www.bostonscientific.com/templatedata/imports/Microsite/Stone/collateral/Percuflex-Brochure.pdf Ureteral Stent portfolio] Net sales |thumb|center|1000px| All figures in 2010 – USD 7.8 Billion Share of Urology- 8.48 % Net sales from Urology- USD 661 Million Source [http://phx.corporate-ir.net/phoenix.zhtml?c=62272&p=irol-reportsother BSsalesdatamillion ] ====CR BARD==== [[Urology portfolio]] Net sales in 2010 – USD 2.7 Billion Share of Urology- 26% Net sales from Urology- USD 702 Million Source – CR BARD annual report ====Cook Medical==== [http://www.cookmedical.com/uro/familyListingAction.do?family=Ureteral+Stents Ureteral Stent portfolio] Total Sales - USD 1.7 Billion [http://www.nytimes.com/2011/04/26/business/26cook.html?_r=1 Source] ====Medline==== [http://www.medline.com/irj/catalog/search?initialSearchTerms=ureteral%20stent Ureteral Stent Portfolio]
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