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Smart miniature drug delivery systems

2,112 bytes added, 06:54, 17 June 2011
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===Introduction===
*'''The smart miniature drug delivery sytemsystem''' is for delivering the drugs to the host.Biological information is detected by biological sensors, the information is analyzed and drug delivery system is actuated to deliver the drug based on the information.
*This system utilizes MEMS or NEMS technology based drug pumps, micro-pumps, micro-needles, micro-osmotic pumps, Nano-pumps.
*It also includes sensors or communication systems to activate or control pumps.
*Microsystems technologies are changing the Life Sciences industry. New in vitro diagnostic systems, new therapy strategies, genetic diseases treatment, targeted and intelligent drug delivery, artificial pancreas, drug discovery processes are health improvement promised to the future generations, enabled by semiconductor and MEMS technologies. The Life Sciences industry already faces critical challenges to take its way to its expected market.
*The bar graph below gives details of the MEMS component for lifescience market
[[Image:Biomems.jpg|center|thumb|500px|'''MEMS component lifescience market''' [http://www.sensorsportal.com/HTML/IFSA_Newsletter_February_08.htm Source ]]]
*Micro- and nano-electromechanical systems (MEMS or NEMS)-based drug delivery devices offer opportunities to address unmet medical needs related to dosing. Such devices should be considered when conventional dosing methods perform suboptimally in terms of safety, efficacy, pain, or convenience. In addition, applications of these technologies may create totally new drug delivery paradigms. MEMS technologies may create new therapies with existing molecular entities.
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[[Image:micropump.jpg|thumb|right|280px| Micropump [http://www.ophthalmotronics.com/index-1.html Source]]]
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*Although any kind of small pump is often referred to as micropump, a more accurate and up-to-date definition restricts this term to pumps with functional dimensions in the micrometre range. Such pumps are of special interest in microfluidic research, and have become available for industrial product integration in recent years. Their miniaturized overall size, potential cost and improved dosing accuracy compared to existing miniature pumps fuel the growing interest for this innovative kind of pump.
*Micropumps can be grouped into mechanical and non-mechanical devices: Mechanical systems contain moving parts, which are usually actuation and valve membranes or flaps. The driving force can be generated by utilizing piezoelectric, electrostatic, thermo-pneumatic, pneumatic or magnetic effects. Non-mechanical pumps function with electro-hydrodynamic, electro-osmotic or ultrasonic flow generation.  [http://en.wikipedia.org/wiki/Micropump Source][[Image:micropump.jpg|thumb|center|300px| Micropump [http://www.ophthalmotronics.com/index-1.html Source]]]<br><br>
==='''Microneedles'''===
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[[Image:microneedle.jpg|right|Thumb|300px| Microneedles for drug delivery[http://www.scf-online.com/english/37_e/skinpenetration37_e.htm Source]]]
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*Microneedles were first developed as a method for transdermal drug delivery . The microneedles
are long enough to penetrate the stratum corneum, which often acts as the primary barrier
potentially offering a painless method for drug delivery.
*The microneedles can be divided into "In-Plane" and "Out of plane" microneedle based o fabrication methods and as "Hollow" and "Solid" Microneedles based on their physical aspects.
[[Image:microneedle.jpg|center|Thumb|300px| Microneedles for drug delivery[http://www.scf-online.com/english/37_e/skinpenetration37_e.htm Source]]]
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=='''TaxanomyTaxonomy'''==[[Image:taxanomy2.jpg|center|thumb|500px700px|'''TaxanomyTaxonomy''']]
==Search concepts==
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#8080804F81BD" rowspan = "2"|<font color="#FFFF00FFFFFF">'''SrS. No.'''</font>|align = "center" bgcolor = "#8080804F81BD"|<font color="#FFFF00FFFFFF">'''Concept 1'''</font>|align = "center" bgcolor = "#8080804F81BD"|<font color="#FFFF00FFFFFF">'''Concept 2'''</font>|align = "center" bgcolor = "#8080804F81BD"|<font color="#FFFF00FFFFFF">'''Concept 3'''</font>|align = "center" bgcolor = "#8080804F81BD"|<font color="#FFFF00FFFFFF">'''Concept 4'''</font>|align = "center" bgcolor = "#8080804F81BD"|<font color="#FFFF00FFFFFF">'''Concept 5'''</font>|align = "center" bgcolor = "#8080804F81BD"|<font color="#FFFF00FFFFFF">'''Concept 6'''</font> 
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|align = "center" bgcolor = "#80808095B3D7"|<font color="#FFFF00">'''1Mems'''</font>|align = "center" bgcolor = "#33CCCC95B3D7"|'''MEMSNems'''|align = "center" bgcolor = "#33CCCC95B3D7"|'''NEMSDrug'''|align = "center" bgcolor = "#33CCCC95B3D7"|'''DRUGSensor'''|align = "center" bgcolor = "#33CCCC95B3D7"|'''SENSORCommunication'''|align = "center" bgcolor = "#33CCCC95B3D7"|'''COMMUNICATIONDelivery'''|align = "center" bgcolor = "#33CCCC"|'''DELIVERY''' 
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|align = "center" bgcolor = "#808080DBE5F1"|<font color="#FFFF00">'''2'''</font>1|align bgcolor = "center#DBE5F1"|Microelectromechanical Systems|align bgcolor = "center#DBE5F1"|Nanoelectromechanical systemsSystems|align bgcolor = "center#DBE5F1"|Medicament|align bgcolor = "center#DBE5F1"|Biosensor|align bgcolor = "center#DBE5F1"|Bioinformation technology|align bgcolor = "center#DBE5F1"|Inject<nowiki>*</nowiki>4  
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|align = "center" bgcolor = "#808080"|<font color="#FFFF00">'''3'''</font>2|align = "center"|Microsystem Technology|align = "center"|BioNems|align = "center"|Pharmaceutic<nowiki>*</nowiki>2|align = "center"|Smartsensor|align = "center"|Telemetry|align = "center"|Perfus<nowiki>*</nowiki>
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|align = "center" bgcolor = "#808080DBE5F1"|<font color="#FFFF00">'''4'''</font>3|align bgcolor = "center#DBE5F1"|BioMems|align bgcolor = "center#DBE5F1"|NanoneedleNanopump|align bgcolor = "center#DBE5F1"|Medic<nowiki>*</nowiki>5|align bgcolor = "center#DBE5F1"|Microsensor|align bgcolor = "center#DBE5F1"|&nbsp;|align bgcolor = "center#DBE5F1"|Infus<nowiki>*</nowiki>
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|align = "center" bgcolor = "#808080"|<font color="#FFFF00">'''5'''</font>4|align = "center"|Micropump|align = "center"|Nanopump|align = "center"|&nbsp;|align = "center"|&nbsp;|align = "center"|&nbsp;|align = "center"|Diffus<nowiki>*</nowiki>3  
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|align = "center" bgcolor = "#808080DBE5F1"|<font color="#FFFF00">'''6'''</font>5|align bgcolor = "center#DBE5F1"|Microneedle|align bgcolor = "center#DBE5F1"|&nbsp;|align bgcolor = "center#DBE5F1"|&nbsp;|align bgcolor = "center#DBE5F1"|&nbsp;|align bgcolor = "center#DBE5F1"|&nbsp;|align bgcolor = "center#DBE5F1"|Releas<nowiki>*</nowiki>
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|align = "center" bgcolor = "#808080"|<font color="#FFFF00">'''7'''</font>6|align = "center"|Mems Drugpump|align = "center"|&nbsp;|align = "center"|&nbsp;|align = "center"|&nbsp;|align = "center"|&nbsp;|align = "center"|&nbsp; 
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|align = "center" bgcolor = "#808080DBE5F1"|<font color="#FFFF00">'''8'''</font>7|align bgcolor = "center#DBE5F1"|Microosmotic pumpLab micro chip|align bgcolor = "center#DBE5F1"|&nbsp;|align bgcolor = "center#DBE5F1"|&nbsp;|align bgcolor = "center#DBE5F1"|&nbsp;|align bgcolor = "center#DBE5F1"|&nbsp;|align bgcolor = "center#DBE5F1"|&nbsp; 
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|align = "center" bgcolor |8|Microosmotic pump| | | | | |-|align = "#808080center"|<font colorbgcolor ="#FFFF00DBE5F1">'''|9'''</font>|align bgcolor = "center#DBE5F1"|Lab on a chip|align bgcolor = "center#DBE5F1"|&nbsp;|align bgcolor = "center#DBE5F1"|&nbsp;|align bgcolor = "center#DBE5F1"|&nbsp;|align bgcolor = "center#DBE5F1"|&nbsp;|align bgcolor = "center#DBE5F1"|&nbsp; 
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|align = "center" bgcolor = "#808080"|<font color="#FFFF00">'''10'''</font>
|align = "center"|Lab micro chip
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==Search strategy==
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#CCFFCC4F81BD" colspan |<font color= "6#FFFFFF">'''S. No.'''</font>|align = "center" bgcolor = "#4F81BD"|<font size color= "4#FFFFFF">Micropat'''Concept'''</font>|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Search Query'''</font>|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Scope'''</font>|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Year'''</font>|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Hits'''</font>
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|align = "center" bgcolor = "#969696DBE5F1"|<font color1|bgcolor ="#FFFF99DBE5F1">'''Sr. No'''</font>|MEMS|align = "center" bgcolor = "#969696DBE5F1"|(((Microelectromechanical) OR (Micro ADJ ((System<font color="#FFFF99"nowiki>'''Concept'''*</fontnowiki>|align = "center" bgcolor = "#969696"|1 ADJ Technology) OR (Electromechanical))) OR (MEMS) OR (BioMEMS) OR (Bio ADJ2 MEMS) OR (Microtechnology) OR (Micro ADJ Electro ADJ Mechanical)) OR (Drug ADJ2 Pump) OR (Micro ADJ2 Pump<font color="#FFFF99"nowiki>*</nowiki>1) OR(Micro ADJ2 Needle<nowiki>'''Search Query'''*</fontnowiki>) OR (Micro ADJ2 Osmotic<nowiki>*</nowiki>) OR Micropump<nowiki>*</nowiki> OR Microneedle<nowiki>*</nowiki> OR Microosmotic<nowiki>*</nowiki> OR (Lab ADJ on ADJ a ADJ chip)OR (Lab ADJ2 Micro ADJ2 Chip))|align = "center" bgcolor = "#969696DBE5F1"|<font color="#FFFF99">'''Scope'''<Title/Abstract/font>Claims|align = "center" bgcolor = "#969696DBE5F1"|<font color="#FFFF99">'''Year'''</font>1836-2009|align = "centerright" bgcolor = "#969696DBE5F1"|<font color="#FFFF99">'''Hits'''</font>24396
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|align = "center" bgcolor = "#969696"|<font color="#FFFF99">'''1'''</font>2|align = "center"|'''MEMS'''NEMS|(((Microelectromechanical) Nanoelectromechanical OR NEMS OR (Micro Nano ADJ ((System*1 ADJ Technology) OR (Electromechanical))) OR (MEMS) OR (BioMEMS) OR (Bio ADJ2 MEMS) OR (Microtechnology) OR (Micro Nano ADJ Electro ADJ Mechanical)) OR BioNEMS OR (Drug Bio ADJ2 PumpNEMS) OR (Micro ADJ2 Nano ADJ Pump<nowiki>*</nowiki>1) OR Nanopump OR(Micro Nano ADJ2 Needle<nowiki>*</nowiki>1) OR (Micro ADJ2 OsmoticNanoneedle<nowiki>*) OR Micropump* OR Microneedle* OR Microosmotic* OR (Lab ADJ on ADJ a ADJ chip)OR (Lab ADJ2 Micro ADJ2 Chip)</nowiki>1)|Title/Abstract/Claims |align = "center"|1836-2009|align = "centerright"|<font color="#3366FF">24396</font>474
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|align = "center" bgcolor = "#969696DBE5F1"|<font color3|bgcolor ="#FFFF99DBE5F1">'''2'''</font>|Drug Delivery|align bgcolor = "center#DBE5F1"|'''NEMS'''|(Nanoelectromechanical Drug OR NEMS Pharmaceutic<nowiki>*</nowiki>2 OR (Nano ADJ ElectromechanicalMedic<nowiki>*</nowiki>5) OR Near10 (Nano ADJ Electro ADJ Mechanical) Deliver<nowiki>*</nowiki>4 OR BioNEMS Inject<nowiki>*</nowiki>4 OR (Bio ADJ2 NEMS) OR (Nano ADJ PumpPerfus<nowiki>*1) </nowiki>3 OR Nanopump Infus<nowiki>*</nowiki>3 OR (Nano ADJ2 NeedleDiffus<nowiki>*1) </nowiki>3 OR NanoneedleReleas<nowiki>*1</nowiki>)|Title/Abstract/Claims bgcolor = "#DBE5F1"|Full Spec|align bgcolor = "center#DBE5F1"|1836-2009|align = "centerright"|<font colorbgcolor ="#3366FFDBE5F1">474</font>|336156
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|align = "center" bgcolor = "#969696"|<font color="#FFFF99">'''3'''</font>4|align = "center"|''' Drug Delivery'''Sensor/Communication|(Drug OR Pharmaceutic<nowiki>*2 </nowiki>sensor) OR Medic(Sensor<nowiki>*5</nowiki>1) Near10 (Deliver*4 OR Inject*4 OR PerfusCommunicat<nowiki>*</nowiki>3 OR Infus*3 Telemetry OR Diffus*3 (Bio ADJ2 IT) OR Releas*(Bio ADJ2 Information)|Full SpecTitle/Abstract/Claims|align = "center"|1836-2009|align = "centerright"|<font color="#3366FF">336156</font>3257001
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|align = "center" bgcolor = "#969696DBE5F1"|<font color5|bgcolor ="#FFFF99DBE5F1">'''4'''</font>|Final Query|align bgcolor = "center#DBE5F1"|'''Sensor/Communication'''| (*sensor) 1 OR (Sensor*12) OR Communicat*AND 3 OR Telemetry OR (Bio ADJ2 IT) OR (Bio ADJ2 Information)AND 4|Title/Abstract/Claims bgcolor = "#DBE5F1"| |align bgcolor = "center#DBE5F1"|1836-2009|align = "centerright"|<font colorbgcolor ="#3366FFDBE5F1">3257001</font>|1225(531 unique patents)
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|align = "center" bgcolor = "#969696"|<font color="#FFFF99">'''5'''</font>
|align = "center" bgcolor = "#FFCC99"|'''Final Query'''
|align = "center" bgcolor = "#FFCC99"|'''(1 OR 2) AND 3 AND 4'''
|bgcolor = "#FFCC99"|&nbsp;
|align = "center" bgcolor = "#FFCC99"|&nbsp;
|align = "center" bgcolor = "#FFCC99"|<font color="#3366FF">'''1225('''</font><font color="#993300">'''531 unique patents'''</font><font color="#3366FF">''')'''
 
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[[Image:microneedlepatent.jpg|center|thumb|400px|'''Microneedle Patent category Distribution''']]
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