Changes
/* Dolcera Dashboard */
*Product analysis is done for seven products.
[[Image:Nanojet Microneedles.png|right|thumb|450px|'''[http://www.debiotech.com/ Nanojet Microneedles]''']]
[[Image:Jewel Pump.png|right|thumb|200px|'''[http://www.diabetesmine.com/2010/06/ada-device-report-new-jewel-pump-is-best-in-show.html Jewel Pump]''']]
==Introduction==
*The smart drug delivery system is used for delivering drugs to the host. Biological information detected by biological sensors is analyzed and the drug delivery system is actuated to deliver the drug based on the information.
*The system utilizes MEMS or NEMS technology based drug pumps, micro-pumps, micro-needles, micro-osmotic pumps, and nano-pumps.
[https://dolcera.net/teamwiki_prod/index.php/smart_drug_delivery_background read more...]
==Smart Drug Delivery Systems: Search conceptsStrategy=====Control Patents==={|border="2" cellspacing="0" cellpadding="4" width="100%"|align = "center" bgcolor = "#4F81BD" width="38"|<font color="#FFFFFF">'''S. No.'''</font>|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Patent/Publication No.'''</font>|align = "center" bgcolor = "#4F81BD" width ="105"|<font color="#FFFFFF">'''Publication Date'''<br>(mm/dd/yyyy)</font>|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Assignee / Applicant'''</font>|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Title'''</font>|--valign="top"|align = "center" bgcolor = "#DBE5F1"|1|bgcolor = "#DBE5F1"|<font color="#0000FF"><u>[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6723086.PN.&OS=PN/6723086&RS=PN/6723086 US6723086]</u></font>|align = "center" bgcolor = "#DBE5F1"|04/20/04|bgcolor = "#DBE5F1"|Logiq Wireless Solutions|bgcolor = "#DBE5F1"|Remote controlled transdermal medication delivery device|--valign="top"|align = "center"|2|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070071596%22.PGNR.&OS=DN/20070071596&RS=DN/20070071596 US20070071596]</u></font>|align = "center"|03/29/07|Sensile PatAG|Liquid drug delivery micropump|--valign="top"|align = "center" bgcolor = "#DBE5F1"|3|bgcolor = "#DBE5F1"|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060283465%22.PGNR.&OS=DN/20060283465&RS=DN/20060283465 US20060283465]</u></font>|align = "center" bgcolor = "#DBE5F1"|12/21/06|bgcolor = "#DBE5F1"|Hewlett-Packard Development Company|bgcolor = "#DBE5F1"|Smart drug delivery system and a method of implementation thereof|--valign="top"|align = "center"|4|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050187515%22.PGNR.&OS=DN/20050187515&RS=DN/20050187515 US20050187515]</u></font>|align = "center"|08/25/05|Advanced Neuromodulation Systems|Reduced size programmable drug pump|--valign="top"|align = "center" bgcolor = "#DBE5F1"|5|bgcolor = "#DBE5F1"|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040220498%22.PGNR.&OS=DN/20040220498&RS=DN/20040220498 US20040220498]</u></font>|align = "center" bgcolor = "#DBE5F1"|11/04/04|bgcolor = "#DBE5F1"|None|bgcolor = "#DBE5F1"|Micro medical-lab-on-a-chip in a lollipop as a drug delivery device and/or a health monitoring device|--valign="top"|align = "center"|6|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060271020%22.PGNR.&OS=DN/20060271020&RS=DN/20060271020 US20060271020]</u></font>|align = "center"|11/30/06|Chrono Therapeutics|Portable drug delivery device including a detachable and replaceble administration or dosing element|--valign="top"|align = "center" bgcolor = "#DBE5F1"|7|bgcolor = "#DBE5F1"|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080161779%22.PGNR.&OS=DN/20080161779&RS=DN/20080161779 US20080161779]</u></font>|align = "center" bgcolor = "#DBE5F1"|07/03/08|bgcolor = "#DBE5F1"|None|bgcolor = "#DBE5F1"|Implantable nano pump for drug delivery|-|} ===Concept Table===
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#4F81BD" rowspan = "2" width="38"|<font color="#FFFFFF">'''S. No.'''</font>
===English Keyword Search===
Database: '''MicroPatent'''<br>
|-
|}
===Article Search===
*Analyzed Patents
[[Media:Sample patent analysis.xls|'''Please click here to download the sample patent analysis sheet''']]
== Patent Ranking==
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#4F81BD" width="38"|<font color="#FFFFFF">'''S. No.'''</font>
|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Patent/Publication Number'''</font>
|align = "center" bgcolor = "#4F81BD" width="140"|<font color="#FFFFFF">'''Node wise Rating'''</font>
|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Patent Granted/Publication Rating'''</font>
|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Forward Citation Count Rating'''</font>
|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Over All Rating'''</font>
|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Over All Ranking'''</font>
|-
|align = "center" bgcolor = "#DBE5F1"|1
|bgcolor = "#DBE5F1"|<font color="#0000FF"><u>[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=7236821.PN.&OS=PN/7236821&RS=PN/7236821 US7236821]</u></font>
|bgcolor = "#DBE5F1"|Abstract: 3
|bgcolor = "#DBE5F1"|Granted: 2
|align = "center" bgcolor = "#DBE5F1"|106
|align = "center" bgcolor = "#DBE5F1"|125
|align = "center" bgcolor = "#DBE5F1"|'''1'''
|-
|align = "center"|2
|<font color="#0000FF"><u>[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6562000.PN.&OS=PN/6562000&RS=PN/6562000 US6562000]</u></font>
|Dependent Claim: 4
|Granted: 2
|align = "center"|34
|align = "center"|58
|align = "center"|'''2'''
|-
|align = "center" bgcolor = "#DBE5F1"|3
|bgcolor = "#DBE5F1"|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080161779%22.PGNR.&OS=DN/20080161779&RS=DN/20080161779 US20080161779]</u></font>
|bgcolor = "#DBE5F1"|Independent Claim: 5
|bgcolor = "#DBE5F1"|Publication: 1
|align = "center" bgcolor = "#DBE5F1"|0
|align = "center" bgcolor = "#DBE5F1"|27
|align = "center" bgcolor = "#DBE5F1"|'''3'''
|-
|align = "center"|4
|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220090306633%22.PGNR.&OS=DN/20090306633&RS=DN/20090306633 US20090306633]</u></font>
|Dependent Claim: 4
|Publication: 1
|align = "center"|0
|align = "center"|22
|align = "center"|'''4'''
|-
|align = "center" bgcolor = "#DBE5F1"|5
|bgcolor = "#DBE5F1"|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220100069888%22.PGNR.&OS=DN/20100069888&RS=DN/20100069888 US20100069888]</u></font>
|bgcolor = "#DBE5F1"|Full Specification: 4
|bgcolor = "#DBE5F1"|Publication: 1
|align = "center" bgcolor = "#DBE5F1"|0
|align = "center" bgcolor = "#DBE5F1"|7
|align = "center" bgcolor = "#DBE5F1"|'''5'''
|-
|}
The patents have been ranked considering the following parameters, prioritized in the given order:
*Taxonomy node
*Granted patent/ Patent publication
*Citation count
Further ranking within the parameters is as given below:
*'''Taxonomy node'''
Independent claim – rank 5<br>
Dependent claim – rank 4<br>
Abstract – rank 3<br>
Title – rank 2<br>
Full specification – rank 1<br>
Background – rank 0<br>
*'''Granted/Publication'''
Granted patent – rank 2<br>
Patent publication – rank 1<br>
*'''Citation Count'''
All citations - rank 1
The weightage assigned for the parameters are:<br>
Taxonomy node multiplied by a factor of 5<br>
Granted Patent/Patent Publication multiplied by a factor of 2<br>
Citation count multiplied by a factor of 1<br>
The overall rating is calculated as shown below considering US7236821 as an example:<br>
Taxonomy node: Abstract – ranking is 3<br>
Granted Patent – ranking is 2<br>
Forward citation count – ranking is 1<br>
Overall rating = (Taxonomy node * weightage 5) + (Granted Patent/Patent Publication * weightage 2) + (Citation count * weightage 1)<br>
=(3*5) + (2*2) + (106*1)<br>
=15 + 4 + 106<br>
=125<br>
The patents are sorted according to the hightest rating values and ranked accordingly.
==Sample Article Analysis==
*Analyzed Articles
[[Media:Sample analysis of articles.xls|'''Please click here to download the sample article analysis sheet''']]
'''Dashboard Link'''<br>
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|'''[httphttps://clientwww.dolcera.com/auth/dashboard/dashboard.htmlphp?workfile_id=915 Smart Drug Delivery Systems - Dashboard] '''
|width="100"|[[Image:dashboard_thumb.png|center|100px|]]
|-
*Flash Player is essential to view the Dolcera dashboard
==InsightsKey Findings==
===Major Players===
*[http://www.medtronic.com/ Medtronic] and [http://www.baxter.com/ Baxter] are the major players in the field of smart drug delivery system.
* Our product search indicates that there are six smart drug delivery devices based on MEMS/NEMS while only three smart drug delivery devices are based on microneedles.
* Out of the six smart drug delivery devices based on MEMS/NEMS, two devices -- [http://professional.medtronic.com/products/isomed-constant-flow-infusion-system/index.htm IsoMed Drug Pump] and [http://professional.medtronic.com/products/synchromed-II-pain/index.htm#tab1 SynchroMed II Drug Pump] -- from [http://www.medtronic.com/ Medtronic] have already been launched into the market. Furthermore, two out of the six [http://www.scribd.com/doc/30749175/Jewel-Pump Jewel Pump] from [http://www.debiotech.com/ Debiotech], and [http://www.mchips.com/products.html MicroCHIPS' delivery device] are in clinical trial stage. These two devices are expected to be launched around the end of the year 2014 in the US.
==Market Analysis==
'''MEMS'''
*MEMS is expected to grow from $8 billion in sales in 2010 to $16.4 billion by 2015, according to Yole Développement, a market research firm based in Lyon, France. The forecast reflects a compound annual growth rate (CAGR) of about 15 percent.
*iSuppli Corp., a market research firm based in El Segundo, Calif., forecasts MEMS device sales to climb from more than $6 billion in 2010 to about $10 billion in 2014, representing a CAGR of 11.6 percent. And it’s possible that growth rate could continue through 2020, bringing the MEMS market to more than $20 billion.[http://www.micromanufacturing.com/showthread.php?t=981 Source]
*One difference in the two forecasts is emerging MEMS markets in borderline device like electronic-compasses, which Yole counts but iSuppli does not include. Also, iSuppli only counts microfluidic devices cast on silicon substrates, whereas Yole includes microfluidics on polymer and glass substrates. [http://www.eetimes.com/electronics-news/4210412/Analysts-split-on-MEMS-growth-rate-forcasts Source]
[[Image:MEMS Revenue.png|center|600px|]]
'''Drug Delivery'''
*The estimate for advanced drug delivery systems for 2014 is $196.4 billion, for a compound annual growth rate (CAGR) of 7.2% in the 5-year period.
*The largest segment of the market is targeted drug delivery, which is expected to increase to $80.2 billion in 2014, for a CAGR of 9.5%.
*Sustained-release products have the second-largest market share, with estimated sales of $45.8 billion in 2014, for a CAGR of 4.9%. [http://www.bccresearch.com/report/PHM006G.html Source]
[[Image:MEMS Drug Delivery.png|center|600px|]]
*Major changes such as an aging population and growing obesity issues in many countries (leading for example to diabetes or other disorders) are impacting the medical MEMS market. These and other factors are among the motivations for making treatments less invasive or for monitoring the movements of the elderly. MEMS used in insulin pumps increase the efficacy and comfort of insulin drug delivery, for instance, while accelerometers monitor elderly people, tirelessly watching their movements, their position or presence in a bed, if they fall, and so on.
*Pressure sensors monitor gases during surgical operations or the treatment of sleep apnea. Accelerometers and gyroscopes assist surgeons by removing shake during precise operations. Emerging applications include implantable wireless pressure sensors, which are showing great promise in monitoring tell tale pressure buildup following heart surgery and are used for post-op monitoring of aneurisms. As a result markets for medical diagnostics and drug delivery devices enjoy 34% and 32% CAGR respectively from 2009 to 2014. [http://www.electroiq.com/index/display/nanotech-article-display/9401887432/articles/small-times/nanotechmems/mems/mems-applications/2010/12/quiet-revolution_.html Source]
*The global market for MEMS used in medical applications is forecasted to reach $430 million by 2014, up from $229 million in 2009, equating to a CAGR of 13 percent, as shown in the figure.
[[Image:MEMS_Medical Application.png|center|600px|]]
*[http://www.diabetesmine.com/2010/06/ada-device-report-new-jewel-pump-is-best-in-show.html Jewel Pump]
*[http://dolcera.com/wiki/index.php?title=Smart_Drug_Delivery_Systems#Control_Patents Control Patents]
*[http://professional.medtronic.com/products/isomed-constant-flow-infusion-system/index.htm IsoMed Drug Pump]
*[http://professional.medtronic.com/products/synchromed-II-pain/index.htm#tab1 SynchroMed II Drug Pump]
*[http://www.medtronic.com/ Medtronic]
*[http://www.debiotech.com/ Debiotech]
*[http://www.mchips.com/products.html MicroCHIPS' delivery device]
*[http://www.micromanufacturing.com/showthread.php?t=981 MEMS Market Analysis]
*[http://www.eetimes.com/electronics-news/4210412/Analysts-split-on-MEMS-growth-rate-forcasts MEMS Market Analysis]
*[http://www.bccresearch.com/report/PHM006G.html Drug Delivery Market Analysis]
*[http://www.electroiq.com/index/display/nanotech-article-display/9401887432/articles/small-times/nanotechmems/mems/mems-applications/2010/12/quiet-revolution_.html Drug Delivery Market Analysis]
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