Changes
/* Dolcera Dashboard */
*The IP information, competitor activity and the technology classification are also included.
*Prior art problems and their respective solutions given in different patents are captured in addition to the taxonomy nodes(technology breakdown classification).
*Product to patent mapping analysis is done for seven products. [[Image:Nanojet Microneedles.png|right|thumb|450px|'''[http://www.debiotech.com/ Nanojet Microneedles]''']][[Image:Jewel Pump.png|right|thumb|200px|'''[http://www.diabetesmine.com/2010/06/ada-device-report-new-jewel-pump-is-best-in-show.html Jewel Pump]''']]
==Introduction==
*The smart miniature drug delivery system is used for delivering drugs to the host. Biological information detected by biological sensors is analyzed and the drug delivery system is actuated to deliver the drug based on the information.*The system utilizes MEMS or NEMS technology based drug pumps, micro-pumps, micro-needles, micro-osmotic pumps,and nano-pumps.
*MEMS based drug delivery systems provide enhanced drug therapy which allows accurate dosing with more efficacy and effectiveness. The application of MEMS for drug delivery through biocapsules, microneedles, and micropumps offers a less invasive drug therapy and improves the quality of life of the patients.
*It also includes sensors or communication systems to remotely activate or control the pumps.
[https://dolcera.net/teamwiki_prod/index.php/smart_drug_delivery_background read more...]
==Smart Drug Delivery Systems: Search conceptsStrategy=====Control Patents==={|border="2" cellspacing="0" cellpadding="4" width="100%"|align = "center" bgcolor = "#4F81BD" width="38"|<font color="#FFFFFF">'''S. No.'''</font>|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Patent/Publication No.'''</font>|align = "center" bgcolor = "#4F81BD" width ="105"|<font color="#FFFFFF">'''Publication Date'''<br>(mm/dd/yyyy)</font>|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Assignee / Applicant'''</font>|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Title'''</font>|--valign="top"|align = "center" bgcolor = "#DBE5F1"|1|bgcolor = "#DBE5F1"|<font color="#0000FF"><u>[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6723086.PN.&OS=PN/6723086&RS=PN/6723086 US6723086]</u></font>|align = "center" bgcolor = "#DBE5F1"|04/20/04|bgcolor = "#DBE5F1"|Logiq Wireless Solutions|bgcolor = "#DBE5F1"|Remote controlled transdermal medication delivery device|--valign="top"|align = "center"|2|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070071596%22.PGNR.&OS=DN/20070071596&RS=DN/20070071596 US20070071596]</u></font>|align = "center"|03/29/07|Sensile PatAG|Liquid drug delivery micropump|--valign="top"|align = "center" bgcolor = "#DBE5F1"|3|bgcolor = "#DBE5F1"|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060283465%22.PGNR.&OS=DN/20060283465&RS=DN/20060283465 US20060283465]</u></font>|align = "center" bgcolor = "#DBE5F1"|12/21/06|bgcolor = "#DBE5F1"|Hewlett-Packard Development Company|bgcolor = "#DBE5F1"|Smart drug delivery system and a method of implementation thereof|--valign="top"|align = "center"|4|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050187515%22.PGNR.&OS=DN/20050187515&RS=DN/20050187515 US20050187515]</u></font>|align = "center"|08/25/05|Advanced Neuromodulation Systems|Reduced size programmable drug pump|--valign="top"|align = "center" bgcolor = "#DBE5F1"|5|bgcolor = "#DBE5F1"|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040220498%22.PGNR.&OS=DN/20040220498&RS=DN/20040220498 US20040220498]</u></font>|align = "center" bgcolor = "#DBE5F1"|11/04/04|bgcolor = "#DBE5F1"|None|bgcolor = "#DBE5F1"|Micro medical-lab-on-a-chip in a lollipop as a drug delivery device and/or a health monitoring device|--valign="top"|align = "center"|6|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060271020%22.PGNR.&OS=DN/20060271020&RS=DN/20060271020 US20060271020]</u></font>|align = "center"|11/30/06|Chrono Therapeutics|Portable drug delivery device including a detachable and replaceble administration or dosing element|--valign="top"|align = "center" bgcolor = "#DBE5F1"|7|bgcolor = "#DBE5F1"|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080161779%22.PGNR.&OS=DN/20080161779&RS=DN/20080161779 US20080161779]</u></font>|align = "center" bgcolor = "#DBE5F1"|07/03/08|bgcolor = "#DBE5F1"|None|bgcolor = "#DBE5F1"|Implantable nano pump for drug delivery|-|} ===Concept Table===
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#4F81BD" rowspan = "2" width="38"|<font color="#FFFFFF">'''S. No.'''</font>
===English Keyword Search===
Database: '''MicroPatent'''<br>
|--valign="top"
|align = "center" bgcolor = "#DBE5F1"|7
|bgcolor = "#DBE5F1"|Combined Query
|bgcolor = "#DBE5F1"|4 AND 6
|bgcolor = "#DBE5F1"|<nowiki>-</nowiki>
|--valign="top"
|align = "center" bgcolor = "#DBE5F1"|7
|bgcolor = "#DBE5F1"|Combined Query
|bgcolor = "#DBE5F1"|4 AND 6
|bgcolor = "#DBE5F1"|
|-
|align = "center" bgcolor = "#DBE5F1"|1
|align = "center" bgcolor = "#DBE5F1"|1991010101/01/1991 -2011010101/01/2011
|align = "center" bgcolor = "#DBE5F1"|3C081
|align = "center" bgcolor = "#DBE5F1"|<nowiki>[</nowiki>EA32<nowiki>+</nowiki>EA29<nowiki>+</nowiki>EA31<nowiki>+</nowiki>EA33<nowiki>]*</nowiki>EA39
|-
|}
===Article Search===
|-
|}
=='''Taxonomy'''==
|bgcolor = "#DBE5F1"|Logiq Wireless Solutions
|bgcolor = "#DBE5F1"|Remote controlled trans-dermal medication delivery device
|bgcolor = "#DBE5F1"|Ambulatory individuals requiring long term medication need to take medications at inconvenient times, in awkward locations, or have to stay at home to follow their medication regime; Oral administration leads to side effects with blood medication levels sometimes rising to toxic levels or falling to subtherapeutic levels|bgcolor = "#DBE5F1"|Trans-dermal Transdermal medication delivery provides constant and continuous absorption of the drug while allowing the patient to remain ambulatory while receiving the medication, trans-dermal ; transdermal drug delivery eliminate factors such as pH changes and food intake that influence gastrointestinal absorption, ; transdermal medication delivery device allows the vital signs of a patient to be monitored from a remote location.
|--valign="top"
|align = "center"|2
|Koninklijke Philips Electronics
|Electronically controlled capsule
|When taking medications in te the form of capsules, a log has to be maintained regarding what capsules has to be administered and at what intervals of time; Time-release capsules do not follow an exact dispensing or dissolving pattern while traveling through the alimentary tract
|Electronically controlled capsule for delivering or dispensing a medicament according to a preset dispensing timing pattern while traversing through the gastrointestinal tract; Electronically controlled capsule allows a person to take all capsules substantially simultaneously, so that no more capsules are required for the day;
|--valign="top"
|bgcolor = "#DBE5F1"|Implantable nano pump for drug delivery
|bgcolor = "#DBE5F1"|Detecting, evaluating, and treating people with hypertension wherein the drug treatment has its mix of favorable and unfavorable effects, costs and sometimes the treatment is inadequate.
|bgcolor = "#DBE5F1"|A real-time, self-actuated nanopumps nano-pumps that respond to different blood pressure, blood lipid or blood glucose levels by having membranes of varying thickness, thus enabling multi-level blood pressure drug release.
|--valign="top"
|align = "center"|4
|bgcolor = "#DBE5F1"|Medtronic
|bgcolor = "#DBE5F1"|Single-use therapeutic substance delivery device with infusion rate control
|bgcolor = "#DBE5F1"|Single-use devices are typically configured with a preset infusion rate and hence there ia is a need for variable infusion rate controlled drug delivery device.|bgcolor = "#DBE5F1"|The single-use therapeutic substance delivery device is provided with infusion rate control, is versatile, small, and inexpensive
|--valign="top"
|align = "center"|6
|Biosynchronous transdermal drug delivery
|Failure to comply with a dosing regimen - rigid dosing schedule, forgetfulness or denial of a medical condition; There is a need for a non-invasive, reliable means of delivering drugs compounds in precisely timed and measured doses-without causing any patient inconvenience
|An automated and pre -programmable transdermal drug administration system that can synchronize and tailor drug administration to the human body<nowiki>’</nowiki>s circadian rhythms to deliver varying dosages at varying times. This minimizes negative side effects, and increases efficacy of the dosing regimen.
|--valign="top"
|align = "center" bgcolor = "#DBE5F1"|7
|bgcolor = "#DBE5F1"|Medical device for analyte monitoring and drug delivery
|bgcolor = "#DBE5F1"|Need for point of care devices that can detect biological macromolecular activity or drug concentration levels and accordingly administer a specific therapeutic agent at a localized site, within the body, in response to changes in biological macromolecular activity or drug concentration levels.
|bgcolor = "#DBE5F1"|Medical device with a biometric recognition device capable of obtaining and comparing physical parameter data of an interaction between the disease marker biological analyte with the bioactive bio-active agent and a therapeutic agent releasing device that controls the release of the therapeutic agent from the reservoirs.
|--valign="top"
|align = "center"|8
[[Media:Sample patent analysis.xls|'''Please click here to download the sample patent analysis sheet''']]
== Patent Ranking==
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#4F81BD" width="38"|<font color="#FFFFFF">'''S. No.'''</font>
|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Patent/Publication Number'''</font>
|align = "center" bgcolor = "#4F81BD" width="140"|<font color="#FFFFFF">'''Node wise Rating'''</font>
|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Patent Granted/Publication Rating'''</font>
|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Forward Citation Count Rating'''</font>
|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Over All Rating'''</font>
|align = "center" bgcolor = "#4F81BD"|<font color="#FFFFFF">'''Over All Ranking'''</font>
|-
|align = "center" bgcolor = "#DBE5F1"|1
|bgcolor = "#DBE5F1"|<font color="#0000FF"><u>[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=7236821.PN.&OS=PN/7236821&RS=PN/7236821 US7236821]</u></font>
|bgcolor = "#DBE5F1"|Abstract: 3
|bgcolor = "#DBE5F1"|Granted: 2
|align = "center" bgcolor = "#DBE5F1"|106
|align = "center" bgcolor = "#DBE5F1"|125
|align = "center" bgcolor = "#DBE5F1"|'''1'''
|-
|align = "center"|2
|<font color="#0000FF"><u>[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6562000.PN.&OS=PN/6562000&RS=PN/6562000 US6562000]</u></font>
|Dependent Claim: 4
|Granted: 2
|align = "center"|34
|align = "center"|58
|align = "center"|'''2'''
|-
|align = "center" bgcolor = "#DBE5F1"|3
|bgcolor = "#DBE5F1"|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080161779%22.PGNR.&OS=DN/20080161779&RS=DN/20080161779 US20080161779]</u></font>
|bgcolor = "#DBE5F1"|Independent Claim: 5
|bgcolor = "#DBE5F1"|Publication: 1
|align = "center" bgcolor = "#DBE5F1"|0
|align = "center" bgcolor = "#DBE5F1"|27
|align = "center" bgcolor = "#DBE5F1"|'''3'''
|-
|align = "center"|4
|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220090306633%22.PGNR.&OS=DN/20090306633&RS=DN/20090306633 US20090306633]</u></font>
|Dependent Claim: 4
|Publication: 1
|align = "center"|0
|align = "center"|22
|align = "center"|'''4'''
|-
|align = "center" bgcolor = "#DBE5F1"|5
|bgcolor = "#DBE5F1"|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220100069888%22.PGNR.&OS=DN/20100069888&RS=DN/20100069888 US20100069888]</u></font>
|bgcolor = "#DBE5F1"|Full Specification: 4
|bgcolor = "#DBE5F1"|Publication: 1
|align = "center" bgcolor = "#DBE5F1"|0
|align = "center" bgcolor = "#DBE5F1"|7
|align = "center" bgcolor = "#DBE5F1"|'''5'''
|-
|}
The patents have been ranked considering the following parameters, prioritized in the given order:
*Taxonomy node
*Granted patent/ Patent publication
*Citation count
Further ranking within the parameters is as given below:
*'''Taxonomy node'''
Independent claim – rank 5<br>
Dependent claim – rank 4<br>
Abstract – rank 3<br>
Title – rank 2<br>
Full specification – rank 1<br>
Background – rank 0<br>
*'''Granted/Publication'''
Granted patent – rank 2<br>
Patent publication – rank 1<br>
*'''Citation Count'''
All citations - rank 1
The weightage assigned for the parameters are:<br>
Taxonomy node multiplied by a factor of 5<br>
Granted Patent/Patent Publication multiplied by a factor of 2<br>
Citation count multiplied by a factor of 1<br>
The overall rating is calculated as shown below considering US7236821 as an example:<br>
Taxonomy node: Abstract – ranking is 3<br>
Granted Patent – ranking is 2<br>
Forward citation count – ranking is 1<br>
Overall rating = (Taxonomy node * weightage 5) + (Granted Patent/Patent Publication * weightage 2) + (Citation count * weightage 1)<br>
=(3*5) + (2*2) + (106*1)<br>
=15 + 4 + 106<br>
=125<br>
The patents are sorted according to the hightest rating values and ranked accordingly.
*Analyzed Articles
[[Media:Sample analysis of articles.xls|'''Please click here to download the sample article analysis sheet''']]
[[Media:product mapping11.xls|'''Click here to download the detailed product-to-patent mapping analysis sheet''']]
==Dolcera Dashboard ==
'''Dashboard Link'''<br>
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|'''[httphttps://clientwww.dolcera.com/auth/dashboard/dashboard.htmlphp?workfile_id=915 Smart Drug Delivery Systems - Dashboard] '''
|width="100"|[[Image:dashboard_thumb.png|center|100px|]]
|-
*Flash Player is essential to view the Dolcera dashboard
==InsightsKey Findings==
===Major Players===
*[http://www.medtronic.com/ Medtronic] and [http://www.baxter.com/ Baxter] are the major players in the field of smart drug delivery system.
* Out of the six smart drug delivery devices based on MEMS/NEMS, two devices -- [http://professional.medtronic.com/products/isomed-constant-flow-infusion-system/index.htm IsoMed Drug Pump] and [http://professional.medtronic.com/products/synchromed-II-pain/index.htm#tab1 SynchroMed II Drug Pump] -- from [http://www.medtronic.com/ Medtronic] have already been launched into the market. Furthermore, two out of the six [http://www.scribd.com/doc/30749175/Jewel-Pump Jewel Pump] from [http://www.debiotech.com/ Debiotech], and [http://www.mchips.com/products.html MicroCHIPS' delivery device] are in clinical trial stage. These two devices are expected to be launched around the end of the year 2014 in the US.
==Market Analysis==
'''MEMS'''
*MEMS is expected to grow from $8 billion in sales in 2010 to $16.4 billion by 2015, according to Yole Développement, a market research firm based in Lyon, France. The forecast reflects a compound annual growth rate (CAGR) of about 15 percent.
*One difference in the two forecasts is emerging MEMS markets in borderline device like electronic-compasses, which Yole counts but iSuppli does not include. Also, iSuppli only counts microfluidic devices cast on silicon substrates, whereas Yole includes microfluidics on polymer and glass substrates. [http://www.eetimes.com/electronics-news/4210412/Analysts-split-on-MEMS-growth-rate-forcasts Source]
[[Image:MEMS Revenue.png|center|600px|]]
'''Drug Delivery'''
*The estimate for advanced drug delivery systems for 2014 is $196.4 billion, for a compound annual growth rate (CAGR) of 7.2% in the 5-year period.
*The largest segment of the market is targeted drug delivery, which is expected to increase to $80.2 billion in 2014, for a CAGR of 9.5%.
*Sustained-release products have the second-largest market share, with estimated sales of $45.8 billion in 2014, for a CAGR of 4.9%. [http://www.bccresearch.com/report/PHM006G.html Source]
[[Image:MEMS Drug Delivery.png|center|600px|]]
*Major changes such as an aging population and growing obesity issues in many countries (leading for example to diabetes or other disorders) are impacting the medical MEMS market. These and other factors are among the motivations for making treatments less invasive or for monitoring the movements of the elderly. MEMS used in insulin pumps increase the efficacy and comfort of insulin drug delivery, for instance, while accelerometers monitor elderly people, tirelessly watching their movements, their position or presence in a bed, if they fall, and so on.
*Pressure sensors monitor gases during surgical operations or the treatment of sleep apnea. Accelerometers and gyroscopes assist surgeons by removing shake during precise operations. Emerging applications include implantable wireless pressure sensors, which are showing great promise in monitoring tell tale pressure buildup following heart surgery and are used for post-op monitoring of aneurisms. As a result markets for medical diagnostics and drug delivery devices enjoy 34% and 32% CAGR respectively from 2009 to 2014. [http://www.electroiq.com/index/display/nanotech-article-display/9401887432/articles/small-times/nanotechmems/mems/mems-applications/2010/12/quiet-revolution_.html Source]
*The global market for MEMS used in medical applications is forecasted to reach $430 million by 2014, up from $229 million in 2009, equating to a CAGR of 13 percent, as shown in the figure.
[[Image:MEMS_Medical Application.png|center|600px|]]
==References==
*[http://www.debiotech.com/ Nanojet Microneedle]
*[http://www.diabetesmine.com/2010/06/ada-device-report-new-jewel-pump-is-best-in-show.html Jewel Pump]
*[http://dolcera.com/wiki/index.php?title=Smart_Drug_Delivery_Systems#Control_Patents Control Patents]
*[http://professional.medtronic.com/products/isomed-constant-flow-infusion-system/index.htm IsoMed Drug Pump]
*[http://professional.medtronic.com/products/synchromed-II-pain/index.htm#tab1 SynchroMed II Drug Pump]
*[http://www.medtronic.com/ Medtronic]
*[http://www.debiotech.com/ Debiotech]
*[http://www.mchips.com/products.html MicroCHIPS' delivery device]
*[http://www.micromanufacturing.com/showthread.php?t=981 MEMS Market Analysis]
*[http://www.eetimes.com/electronics-news/4210412/Analysts-split-on-MEMS-growth-rate-forcasts MEMS Market Analysis]
*[http://www.bccresearch.com/report/PHM006G.html Drug Delivery Market Analysis]
*[http://www.electroiq.com/index/display/nanotech-article-display/9401887432/articles/small-times/nanotechmems/mems/mems-applications/2010/12/quiet-revolution_.html Drug Delivery Market Analysis]
==<span style="color:#C41E3A">Like this report?</span>==
