[[Image:Drug metabolism1.jpg|right|370 px|Drug metabolism]]
==Introduction==
[[Image:Drug metabolism1.jpg|right|250 px|Drug metabolism]]
Drug metabolism is a detoxification function the human body possesses to defend itself from environment hostility.
Ideally, a drug should reach the site of action intact, cure the disease, and leave the body after it completes its mission.
'''Models/Species:'''Male CD1 mouse, male Sprague-Dawley rat, male beagle dog, male cynomolgus monkey and mixed gender human liver microsomes.
===Test Results===
{|border="2" cellspacing="0" cellpadding="4" width="72%"
|align = "center" bgcolor = "#C2D69A" colspan = "7"|'''Pharmacokinetics of GW844520 After Oral Administration to Mouse, Rat, Dog, and Monkey'''
|-
|align = "center" bgcolor = "#8DB4E3"|'''Species'''
|align = "center" bgcolor = "#8DB4E3"|'''Dose (mg/kg)'''
|align = "center" bgcolor = "#8DB4E3"|'''Cmax (µg/mL)'''
|align = "center" bgcolor = "#8DB4E3"|'''Tmax (h)'''
|align = "center" bgcolor = "#8DB4E3"|'''AUC0- (µg h/mL)'''
|align = "center" bgcolor = "#8DB4E3"|'''T1/2 h'''
|align = "center" bgcolor = "#8DB4E3"|'''F (%)'''
|-
|align = "center"|'''Mouse'''
|align = "center"|0.5
|align = "center"|0.28
|align = "center"|4
|align = "center"|8.54
|align = "center"|23.6
|align = "center"|72
|-
|align = "center"|'''Rat'''
|align = "center"|0.5
|align = "center"|0.25 ± 0.02
|align = "center"|2 (1-2)
|align = "center"|4.14 ± 0.96
|align = "center"|7.1 ± 1.7a
|align = "center"|118
|-
|align = "center"|'''Dog'''
|align = "center"|0.4
|align = "center"|0.14 ± 0.02
|align = "center"|24 (4-24)
|align = "center"|22.8 ± 7.9
|align = "center"|214 ± 30
|align = "center"|51 ± 11
|-
|align = "center"|'''Monkey'''
|align = "center"|0.4
|align = "center"|0.12 ± 0.01
|align = "center"|4 (4-8)
|align = "center"|13.5 ± 0.6
|align = "center"|88.4 ± 4.4
|align = "center"|69 ± 6
|}
{|border="2" cellspacing="0" cellpadding="4" width="36%"
|align = "center" bgcolor = "#C2D69A" colspan = "3"|'''In Vitro Cell Partitioning of GW844520 in Animal and Human Blood'''
|-
|align = "center" bgcolor = "#8DB4E3"|'''Species'''
|align = "center" bgcolor = "#8DB4E3"|'''Concentration (µg/mL)'''
|align = "center" bgcolor = "#8DB4E3"|'''Blood to plasma ratio'''
|-
|align = "center" rowspan = "2"|'''Mouse'''
|align = "center"|0.25
|align = "center"|0.56 ± 0.01
|-
|align = "center"|2.5
|align = "center"|0.48 ± 0.02
|-
|align = "center" rowspan = "2"|'''Rat'''
|align = "center"|0.25
|align = "center"|0.50 ± 0.02
|-
|align = "center"|2.5
|align = "center"|0.56 ± 0.03
|-
|align = "center" rowspan = "2"|'''Dog'''
|align = "center"|0.25
|align = "center"|0.52 ± 0.01
|-
|align = "center"|2.5
|align = "center"|0.52 ± 0.01
|-
|align = "center" rowspan = "2"|'''Monkey'''
|align = "center"|0.25
|align = "center"|0.69 ± 0.06
|-
|align = "center"|2.5
|align = "center"|0.62 ± 0.01
|-
|align = "center" rowspan = "2"|'''Human'''
|align = "center"|0.5
|align = "center"|0.54 ± 0.06
|-
|align = "center"|5
|align = "center"|0.60 ± 0.03
|}
{|border="2" cellspacing="0" cellpadding="4" width="62%"
|align = "center" bgcolor = "#9BBB59" colspan = "6"|'''A)Intrinsic clearance CLi, mL/min/g liver'''
|-
|align = "center"|
|align = "center" bgcolor = "#4F81BD"|'''Mouse'''
|align = "center" bgcolor = "#4F81BD"|'''Rat'''
|align = "center" bgcolor = "#4F81BD"|'''Dog'''
|align = "center" bgcolor = "#4F81BD"|'''Monkey'''
|align = "center" bgcolor = "#4F81BD"|'''Human'''
|-
|align = "center" bgcolor = "#4F81BD"|'''Microsomes'''
|align = "center"|0.7
|align = "center"|<nowiki><</nowiki>0.5
|align = "center"|<nowiki><</nowiki>0.5
|align = "center"|<nowiki><</nowiki>0.5
|align = "center"|<nowiki><</nowiki>0.5
|-
|align = "center" bgcolor = "#4F81BD"|'''Hepatocytes'''
|align = "center"|<nowiki><</nowiki>0.5
|align = "center"|3.7
|align = "center"|1.7
|align = "center"|<nowiki><</nowiki>0.5
|align = "center"|<nowiki><</nowiki>0.5
|-
|align = "center" bgcolor = "#9BBB59" colspan = "6"|'''B)CYP450 Inhibition IC50 µM'''
|-
|align = "center"|
|align = "center"|3A4
|align = "center"|1A2
|align = "center"|2D6
|align = "center"|2C9
|align = "center"|2C19
|-
|align = "center"|
|align = "center"|<nowiki>></nowiki>33
|align = "center"|<nowiki>></nowiki>33
|align = "center"|3.0 ± 1.8
|align = "center"|<nowiki>></nowiki>33
|align = "center"|<nowiki>></nowiki>33
|}