* In 1990, a serendipitous discovery showed Botox effect on smoothing wrinkles.
* Consumer adoption happened through off label use (6 years before FDA approval for cosmetic use) due to ''expert buzz' and an existing demand for a wrinkle smoothing product (as shown from number of Collagen procedures that numbered 400,000 in 1997).
* Experts were willing to recommend/try Botox on their patients due to two factors: (A) Safety of Botox (in higher doses for invasive muscular and other disorders) and (B) It's proven discovery to smooth wrinkles .* Suddenly, experts got a substitute for collagen procedures that took more a few months to show perceptible results (as shown below).
===Procedures of Botox vs Collagen===