Changes

Initially botox , Botox was marketed for its medical applications in treating various muscle-related conditions but later , its marketing was broadened to include its cosmetic application—smoothing out frown lines between the eyebrows.<br>

===Annual sales Sales of Botox proceduresProcedures===

'''Conclusions'''* Safety of botox Botox was proven through invasive muscular and neurological procedures very well till by 1992.* In 1990, a serendipitous discovery showed Botox effect on 'smoothing wrinkles'.* Consumer adoption happened through off label use (6 years before FDA approval for cosmetic use) due to 'Expert Buzz'expert buzz' and an existing demand for a 'wrinkle smoothing' product (as shown from number of Collagen procedures that numbered 400,000 in 1997).

* Suddenly , experts got a substitute for collagen procedures that took more a few months to show perceptible results (as shown below)

===Procedures of Botox Vs vs Collagen===Botox and collagen are both invasive procedures used for smoothing of wrinkles and facial lines. With the increase in off-label use and popularity of botox Botox, the market share of collagen has decreased.

===Botox procedures as a percentage of total cosmetic procedures=== [[Image:botox procedures as a percentage.jpg|center|600px|thumb|[http://www.surgery.org/press/statistics.php Botox Procedures as a percentage of total cosmetic proceduresSource: ASAPS]]]