Changes
/* Y-o-Y sale of botox procedures */
Conclusions:-
* Safety of botox was proven through invasive muscular and neurological procedures very well till 1992.
* In 19921990, a serendipitous discovery showed Botox effect on 'smoothing wrinkles'
* Consumer adoption happened through off label use (6 years before FDA approval for cosmetic use) due to 'Expert Buzz' and an existing demand for a 'wrinkle smoothing' product (as shown from number of Collagen procedures that numbered 400,000 in 1997)
* Experts were willing to recommend/try Botox on their patients due to two factors: (A) Safety of Botox (in higher doses for invasive muscular and other disorders) and (B) It's proven discovery to smooth wrinkles
