AN
2004:316145 BIOSIS
DN
PREV200400316750
TI
In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of
hormone-sensitive lipase.
AU
Lowe, Derek B. [Reprint Author]; Magnuson, Steven; Qi, Ning; Campbell,
Ann-Marie; Cook, James; Hong, Zhenqiu; Wang, Ming; Rodriguez, Mareli;
Achebe, Furahi; Kluender, Harold; Wong, Wai C.; Bullock, William H.;
Salhanick, Arthur I.; Witman-Jones, Terri; Bowling, Mary E.; Keiper,
Christine; Clairmont, Kevin B.
CS
Dept Chem, Bayer Res Ctr, 400 Morgan Lane, W Haven, CT, 06516, USA
derek.lowe.b@bayer.com
SO
Bioorganic & Medicinal Chemistry Letters, (June 21 2004) Vol. 14, No. 12,
pp. 3155-3159. print.
CODEN: BMCLE8. ISSN: 0960-894X.
DT
Article
LA
English
ED
Entered STN: 15 Jul 2004
Last Updated on STN: 15 Jul 2004
AB
A series of (5-(2H)-isoxazolonyl) ureas were developed as nanomolar
inhibitors of hormone-sensitive lipase, an enzyme of potential
importance in the treatment of diabetes. Copyright 2004 Elsevier Ltd.
All rights reserved.
CC
Pathology - Therapy 12512
Metabolism - Metabolic disorders 13020
Endocrine - Pancreas 17008
Pharmacology - General 22002
IT
Major Concepts
Pharmacology
IT
Diseases
diabetes: endocrine disease/pancreas, metabolic disease
Diabetes Mellitus (MeSH)
IT
Chemicals & Biochemicals
(5-(2H)-isoxazolonyl) ureas: hormone-sensitive lipase inhibitors,
in vitro structure-activity relationships; hormone-sensitive lipase
IT
Miscellaneous Descriptors
lipolysis
RN
9001-62-1 (hormone-sensitive lipase)