Changes
=== GSK3 inhibition by pyrazole compounds ===
{| border="1" cellpadding="2", style="#008080"
!width="100" bgcolor=DodgerBlue|'''Pyrazole compounds (CAS NUMBER : 288-13-1)'''|- |bgcolor=lightcyan|[http://patft1.uspto.gov/netacgi/nph-Parser?TERM1=6989385+&Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=0&f=S&l=50 US6989385]
[[Image:US6989385.jpg]]
[[Image:US6664247.jpg]]
!width="100" bgcolor=lightcyan|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005012256&F=0 WO2005012256]
[[Image:US6664247.jpg]]
|- style="height:10px"
|bgcolor=lightcyan(a) R<1 >is T-Ring D, wherein T is a valence bond and Ring D is a 5-6 membered aryl or heteroaryl ring; �(b) R<2 >is hydrogen or C1-4 aliphatic and R<2'>is hydrogen; �(c) R<3 >is selected from -R, -OR, or -N(R<4>)2, wherein R is selected from hydrogen, C1-6 aliphatic, 5-6 membered heterocyclyl, phenyl, or 5-6 membered heteroaryl, and L is -O-, -S-, or -NH-; and �(d) Ring D is substituted by up to three substituents selected from -halo, -CN, -NO2, -N(R<4>)2, optionally substituted C1-6 aliphatic group, -OR, -C(O)R, -CO2R, -CONH(R<4>), -N(R<4>)COR, -N(R<4>)CO2R, -SO2N(R<4>)2, -N(R<4>)SO2R, -N(R<6>)COCH2N(R<4>)2, -N(R<6>)COCH2CH2N(R<4>)2, or -N(R<6>)COCH2CH2CH2N(R<4>)2, wherein R is selected from hydrogen, C1-6 aliphatic, phenyl, a 5-6 membered heteroaryl ring, or a 5-6 membered heterocyclic ring
|bgcolor=lightcyan|
|bgcolor=lightcyan|X is a groupR1-A-NR4-or a 5-or 6-membered carbocyclic or heterocyclic ring;
A is a bond,SO2, C=O, NRg (C=O) or O(C=O) wherein Rg is hydrogen orC14 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy;Y is a bond or an alkylene chain of 1,2 or 3 carbon atoms in length;R'is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e. g. fluorine), hydroxy, C1-4 hydrocarbyloxy, amino, mono-ordi-Cl 4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected fromO, S, NH, SO, SO2 ;R2 is hydrogen; halogen;C14 alkoxy (e. g. methoxy); or aC14 hydrocarbyl group optionally substituted by halogen (e. g. fluorine), hydroxyl orC14 alkoxy (e. g. methoxy);R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; andR4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen (e. g. fluorine), hydroxyl or C1-4 alkoxy (e. g. methoxy).
|}
