Changes
/* IP Map for (Anti-androgen + Vasodilators) */
|bgcolor=LightCyan|Inhibits activity of 5-alpha-reductase, protects follicular cell membranes by neutralizing action of oxidation reaction in tissues, stimulates hair follicles and blood circulation to the hair root, supplies oxygen and nutrients to base of follicle, retains humidity, avoids dehydration of scalp
|}
=== Hair matrix cell activator ===
Hair matrix cell activator is a substance that acts at the matrix cells in the hair follicle preventing their degradation.
'''What causes hair loss?'''
* Stem cells are interspersed within the basal layer of the outer root sheath and in an area called the bulge.
* Stem cells migrate to hair matrix where they start to divide and differentiate, under the influence of substances produced by cells of the dermal papilla.
* Perifollicular matrix cells undergo slow degradation which prevents follicle stimulation.
* Hair follicle activation is required for hair growth and thus inhibition of follicle activation eventually leads to hair loss.
'''How does hair cell matrix activator treat hair loss?'''
* Hair cell matrix activator slows down and inhibits degradation of the perifollicular matrix.
* This leads to an increase in hair follicle matrix cells that differentiate from progenitor stem cells.
* Matrix activator allows activation of hair matrix cells and therefore follicle stimulation leading to hair growth.
==== Functions of Hair matrix cell activator ====
[http://www.ijdb.ehu.es/fullaccess/fulltext.04023/ft163.pdf Hair matrix cell activator]
[[Image:Hair matrix.jpg|thumb|center|500px|Functions of Hair matrix cell activator ]]
==== IP Map for Hair matrix cell activator ====
{| border="1" cellpadding="2"
!width="120" bgcolor=DodgerBlue|'''Pat/Pub#'''
!width="100" bgcolor=DodgerBlue|'''Nature'''
!width="200" bgcolor=DodgerBlue|'''Composition'''
!width="600" bgcolor=DodgerBlue|'''Composition action'''
|- style="height:50px"
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220020052498%22.PGNR.&OS=DN/20020052498&RS=DN/20020052498 US20020052498]
SHISEIDO(1999)
|bgcolor=LightCyan|Organic compound
|bgcolor=LightCyan|(2-substituted oxyphenyl) alkanamide derivative and its salt
|bgcolor=LightCyan|Mechanism of action has not been made clear, having excellent hair follicle activating action and regrowth promoting effect
|- style="height:50px"
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040071647%22.PGNR.&OS=DN/20040071647&RS=DN/20040071647 US20040071647]
L'OREAL(1998)
|bgcolor=LightCyan|Peptides
|bgcolor=LightCyan|Metalloprotease (MMP-9) inhibitor (thiol or a hydroxamate) other than chelating calcium ions
|bgcolor=LightCyan|Reducing the expression of MMPs (Metalloproteases) in the scalp - slows down or inhibits the degradation of the perifollicular matrix (extracellular matrix surrounding the hair follicle)
|}
== Technology mapping based on patents analyzed ==
=== IPMap: Composition nature matrix ===
{| border="1" cellpadding="11", style="#008080"
!width="120" bgcolor=DodgerBlue|'''Year'''
!width="200" bgcolor=DodgerBlue|'''Organic Compound'''
!width="200" bgcolor=DodgerBlue|'''Natural extracts'''
!width="200" bgcolor=DodgerBlue|'''Peptides'''
!width="200" bgcolor=DodgerBlue|'''Nucleotides'''
!width="200" bgcolor=DodgerBlue|'''Natural extract + Organic comp'''
|- style="height:10px"
|bgcolor=LightCyan|2005
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|bgcolor=LightCyan|UNILEVER (1)
|-
|bgcolor=LightCyan|2004
|bgcolor=LightCyan|WARNER (1)
|bgcolor=LightCyan|BLOTECH (1)
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|bgcolor=LightCyan|KAO (1)
|-
|bgcolor=LightCyan|2003
|bgcolor=LightCyan|WARNER (1)
|bgcolor=LightCyan|APHIOS (1)
|bgcolor=LightCyan|....
|bgcolor=LightCyan|FUNDACION (1)
|bgcolor=LightCyan|....
|-
|bgcolor=LightCyan|2002
|bgcolor=LightCyan|WARNER (1)
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|-
|bgcolor=LightCyan|2001
|bgcolor=LightCyan |PFIZER (1)
|bgcolor=LightCyan|LG HEALTH-CARE (1)
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|-
|bgcolor=LightCyan|2000
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|bgcolor=LightCyan|L’OREAL (1) / N/A (1)
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|-
|bgcolor=LightCyan|1999
|bgcolor=LightCyan|SHISEDIO (1)
|bgcolor=LightCyan|COLOMER (1)
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|-
|bgcolor=LightCyan|1998
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|bgcolor=LightCyan|L’OREAL (1)
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|-
|bgcolor=LightCyan|1995
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|bgcolor=LightCyan|N/A (1)
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|-
|bgcolor=LightCyan|1987
|bgcolor=LightCyan|....
|bgcolor=LightCyan|KAO (1)
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|-
|bgcolor=LightCyan|1982
|bgcolor=LightCyan|UNILEVER (1)
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|bgcolor=LightCyan|....
|}
=== Focus of patents ===
{| border="1" cellpadding="17", style="#008080"
!width="800" bgcolor=DodgerBlue|'''Focus of patents'''
!width="150" bgcolor=DodgerBlue|'''Patent no.'''
!width="100" bgcolor=DodgerBlue|'''Rec. no.'''
|-
|bgcolor=LightCyan|2-substituted oxyphenyl alkanamide derivative having excellent hair growth effect.
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220020052498%22.PGNR.&OS=DN/20020052498&RS=DN/20020052498 US20020052498]
|bgcolor=LightCyan|1
|-
|bgcolor=LightCyan|Thyromimetic compounds, and its role in treating hair loss
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220030007941%22.PGNR.&OS=DN/20030007941&RS=DN/20030007941 US20030007941]
|bgcolor=LightCyan|2
|-
|bgcolor=LightCyan|Saw Palmetto berry extract, pumpkin seed extract, sitosterol and quercetin for the treatment and prevention of the biologically detrimental effects of DHT
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060009430%22.PGNR.&OS=DN/20060009430&RS=DN/20060009430 US20060009430]
|bgcolor=LightCyan|3
|-
|bgcolor=LightCyan|4-cycloalkoxy benzonitriles and its use as androgen receptor modulators
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060009427%22.PGNR.&OS=DN/20060009427&RS=DN/20060009427 US20060009427]
|bgcolor=LightCyan|4
|-
|bgcolor=LightCyan|Supercritical fluid isolate of Saw Palmetto, Sperol for inhibition of 5-.alpha.-reductase activity
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050118282%22.PGNR.&OS=DN/20050118282&RS=DN/20050118282 US20050118282]
|bgcolor=LightCyan|5
|-
|bgcolor=LightCyan|New class of quinolin-2-ones and chromen-2-ones andtheir use as androgen receptor antagonists
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050085467%22.PGNR.&OS=DN/20050085467&RS=DN/20050085467 US20050085467]
|bgcolor=LightCyan|6
|-
|bgcolor=LightCyan|Antiandrogen oligonucleotides usable for the treatment of dermatological androgen-related disorders
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060009429%22.PGNR.&OS=DN/20060009429&RS=DN/20060009429 US20060009429]
|bgcolor=LightCyan|7
|-
|bgcolor=LightCyan|Bradykinin antagonists for stimulating or inducing hair growth and/or arresting hair loss
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220030073616%22.PGNR.&OS=DN/20030073616&RS=DN/20030073616 US20030073616]
|bgcolor=LightCyan|8
|-
|bgcolor=LightCyan|Extract from walnut leaves and/or pericarps as 5 alpha -reductase inhibitor
|bgcolor=LightCyan|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=EP0279010&F=0 EP0279010]
|bgcolor=LightCyan|9
|-
|bgcolor=LightCyan|Stimulating hair growth using benzopyrans
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040157856%22.PGNR.&OS=DN/20040157856&RS=DN/20040157856 US20040157856]
|bgcolor=LightCyan|10
|-
|bgcolor=LightCyan|Sophora flavescens extract, Coicis semen extract, clove extract, etc for promoting hair growth, function of cell activity and dilating peripheral blood vessels.
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050053572%22.PGNR.&OS=DN/20050053572&RS=DN/20050053572 US20050053572]
|bgcolor=LightCyan|11
|-
|bgcolor=LightCyan|Compositions to prevent or reduce hair loss
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060052405%22.PGNR.&OS=DN/20060052405&RS=DN/20060052405 US20060052405]
|bgcolor=LightCyan|12
|-
|bgcolor=LightCyan|Prostaglandin EP-3 receptor antagonists for reducing hair loss
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050123577%22.PGNR.&OS=DN/20050123577&RS=DN/20050123577 US20050123577]
|bgcolor=LightCyan|13
|-
|bgcolor=LightCyan|Synergic effect arising from the interaction of active ingredients, consisting of three plant extracts and a synthetic organosilicic compound for prevent hair loss and stimulate hair growth
|bgcolor=LightCyan|[http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6447762.PN.&OS=PN/6447762&RS=PN/6447762 US6447762]
|bgcolor=LightCyan|14
|-
|bgcolor=LightCyan|Metalloprotease inhibitors to induce and/or stimulate the growth
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040071647%22.PGNR.&OS=DN/20040071647&RS=DN/20040071647 US20040071647]
|bgcolor=LightCyan|15
|-
|bgcolor=LightCyan|Method of decreasing sebum production and pore size
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050277699%22.PGNR.&OS=DN/20050277699&RS=DN/20050277699 US20050277699 ]
|bgcolor=LightCyan|16
|-
|bgcolor=LightCyan|Method for reducing sebum on the hair and skin
|bgcolor=LightCyan|[http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4529587.PN.&OS=PN/4529587&RS=PN/4529587 US4529587]
|bgcolor=LightCyan|17
|}
=== Technology focus===
[[Image:Technologyfocus2.jpg|thumb|center|700px|Technology focus]]
