Changes

== Introduction ==

* Hair is a complex and delicate part of the body.

* Keeping it healthy and beautiful is a challenge.

[[Image:Hairbasics.jpg|thumb|center|500px|Structure of Hair root and Hair bulb]]

* Decreased growth of the hair

* Increased shedding of the hair

[[Image:Facts.jpg|thumb|right|400px|Survey results from Japan]]

Both men and women lose hair for similar reasons. Hair loss in men is often more dramatic, and follows a specific pattern of loss, one of which has been termed '''“Male Pattern Baldness"''' or '''"Androgenetic Alopecia"'''.

* '''Alopecia Areata (AA):''' Used to describe hair loss occurring in patches anywhere on the body.

* '''Telogen Effluvium:''' A form of hair loss where more than normal amounts of hair fall out. There is a general 'thinning' of the hair. Unlike some other hair and scalp conditions, it is temporary and the hair growth usually recovers. [http://www.alopeciaonline.org.uk/about/types.asp source]

* Gradual Onset.

* Transition from large, thick, pigmented terminal hairs to thinner, shorter, indeterminate hairs and finally to short, wispy, nonpigmented vellus hairs in the involved areas.

* Characterised by a receding hairline and/or hair loss on the top of the head.

* Genetic predisposition

* Hormonal effect of androgen

== Goals ==

The goal of this report is to:

* Summarize IP activity over the years

* Identify major players

b) Nature

c) Action

== IP activity over years ==

[[Image:Year1.jpg|thumb|center|400px|IP Activity over years]]

[[Image:players.jpg|thumb|left|400px|Assignees with more than 20 patents ]]

[[Image:players1.jpg|thumb|center|400px|Assignees with fewer than 20 patents ]]<br>

Assignees currently active with more than 5 patents to their credit during 2000-2005.

* Warner with 9 patents,

[[Image:Active.jpg|thumb|center|500px|Active Assignees]]

== Anti-androgens ==

[[Image:Andogen1.jpg|thumb|center|500px|Functions of Anti-androgen]]

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* Minoxidil is a "potassium channel opener" that leads to vasodilation.

* The drug is available in two forms. Oral minoxidil is used to treat high blood pressure and the topical solution form is used to treat hair loss and baldness.

'''What causes hair loss?'''

== Double action (Anti-androgen + Minoxidil) ==

* Combination of Minoxidil + Anti-androgen (double action) composition for effective treatment of Male-Pattern Baldness.

'''What is the problem with using only Anti-androgen therapy?'''

== Hair matrix cell activator ==

Hair matrix cell activator is a substance that acts at the matrix cells in the hair follicle preventing their degradation.

'''What causes hair loss?'''

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=== IPMap: Composition nature matrix ===

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[[Image:Technologyfocus2.jpg|thumb|center|700px|Technology focus]]

=== Product type vs. Product form ===

[[Image:prod.jpg|thumb|center|700px|Product type vs. Product form]]

=== Patents by target diseases ===

=== Patents by application ===

[[Image:application.jpg|thumb|center|700px|Distribution of patents based on application]]

=== Signaling Pathway and linkages ===