Changes
/* Signaling Pathway and linkages */
* '''Wnt pathway:''' Maintains hair-inducing activity of the dermal papilla.
* '''Hedgehog pathway:''' Sonic hedgehog (SHH) signaling plays a critical role in hair follicle development, but how it controls these processes remains unclear. Skin from mice lacking Sonic hedgehog gene. Sonic hedgehog, SHH have extremely effete for short, helps guide hair follicles with poorly developed dermal papillae, suggesting that from a resting stage into growth activity. SHH controls follicular proliferation, and follicle sizeis particularly important in the embryonic formation of hair follicles.
* '''STAT pathway'''
* '''TGF beta/BMP Pathway:''' Bone morphogenetic protein (BMP) signaling have been implicated in the regulation of both proliferation and differentiation in the hair follicle. BMP2 is expressed in the embryonic ectoderm, but then localizes to the early hair follicle placode and underlying mesenchyme. BMP4 is expressed in the early dermal condensate. Research results show that BMPs are a key component of the signaling network controlling hair development and are required to induce the genetic program regulating hair shaft differentiation in the anagen hair follicle.
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