Changes
/* GSK-3 Inhibition */
* Thus, small molecule inhibitors modeled to fit in the positively charged pocket of the GSK-3 kinease domain could potentially be very effective for selective inhibition of primed substrates.
'''ConclusionProposed mechanisms to regulate GSK-3'''Mechanism to regulate the GSK-3 protein: # inactivation of GSK-3 through serine phosphorylation# activation of GSK-3 through tyrosine phosphorylation# inactivation of GSK-3 through tyrosine dephosphorylation# Covalant modifications of substrates through priming phosphorylation# inhibition or facilation of GSK-3 mediated substrate phosphorylation thriugh interation of GSK-3 with binding or scaffolding proteins# targeting of GSK-3 to different subcellular localizations# differential usage of isoforms or splice variants to alter subcellular localization or substrate specificity# integration of parellel signals conveyed by a signal stimulus.
== Conclusions ==
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