Changes
/* GSK3 inhibition by pyrazole compounds */
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|bgcolor=lightcyan|(a) R<1 >is R1=T-Ring D, wherein T is a valence bond and Ring D is a = 5-6 membered aryl or heteroaryl ring; �(b) R<2 >is R2 = hydrogen or C1-4 aliphatic and R<2R2'>is = hydrogen; �(c) R<3 >is selected from R3 = -R, -OR, or -N(R<4>R4)2, wherein R is selected from = hydrogen, C1-6 aliphatic, 5-6 membered heterocyclyl, phenyl, or 5-6 membered heteroaryl, and L is -O-, -S-, or -NH-; and �(d) Ring D is substituted by up to three substituents selected from -halo, -CN, -NO2, -N(R<4>R4)2, optionally substituted C1-6 aliphatic group, -OR, -C(O)R, -CO2R, -CONH(R<4>), -N(R<4>R4)COR, -N(R<4>R4)CO2R, -SO2N(R<4>R4)2, -N(R<4>R4)SO2R, -N(R<6>R6)COCH2N(R<4>R4)2, -N(R<6>R6)COCH2CH2N(R<4>R4)2, or -N(R<6>R6)COCH2CH2CH2N(R<4>R4)2, wherein R is selected from = hydrogen, C1-6 aliphatic, phenyl, a 5-6 membered heteroaryl ring, or a 5-6 membered heterocyclic ring
|bgcolor=lightcyan|X is a group R<1>-A-NR<4>- or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, S02, C=O, NR<g>(C=O) or O(C=O) wherein R<g> is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R<1> is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g. fluorine), hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from 0, S, NH, SO, S02; R<2> is hydrogen; halogen; C1-4 alkoxy (e.g. methoxy); or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy); R<3> is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R<4> is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy).
|bgcolor=lightcyan|X is a groupR1-A-NR4-or a 5-or 6-membered carbocyclic or heterocyclic ring;
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