Changes

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|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060009427%22.PGNR.&OS=DN/20060009427&RS=DN/20060009427 US20060009427]

|bgcolor=LightCyan|Organic compound

|bgcolor=LightCyan|New class of 4-cycloalkoxy benzonitrile derivatives and salts

|bgcolor=LightCyan|The compounds inhibit, or decrease, activation of androgen receptor by androgens.

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APHIOS Corp (2003)

|bgcolor=LightCyan|Natural extracts

|bgcolor=LightCyan|Supercritical fluid isolate of Saw Palmetto and Sperol (Serenoa repens berry) and their analogs or derivatives.

|bgcolor=LightCyan|Modulates androgenic activity by inhibiting 5.alpha.-reductase activity.

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Fundacion Pablo Cassara (2003)

|bgcolor=LightCyan|Nucleotide

|bgcolor=LightCyan|Pharmacologically active oligonucleotides (encompass both DNA and S-DNA bond)

|bgcolor=LightCyan|Oligonucleotides inhibit androgen receptor (AR) expression at very low concentrations in skin and hair follicle

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PFIZER INC (2001)

|bgcolor=LightCyan|Organic compound

|bgcolor=LightCyan|Thyromimetic compounds (structurally similar to thyronine) with finasteride, or cyproterone acetate

|bgcolor=LightCyan|Activates thyroid hormone receptors in hair follicle which in turn promote elasticisation of follicle walls and hair follicle

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N/A (1995)

|bgcolor=LightCyan|Peptides/nucleic acid

|bgcolor=LightCyan|Bradykinin antagonist (peptide of plasma origin from kininogen precursor-kallikrein)

|bgcolor=LightCyan|Inhibit synthesis of bradykinin receptors or compounds by binding to B2 receptor

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KAO Corp (1987)

|bgcolor=LightCyan|Natural extracts

|bgcolor=LightCyan|Walnut extract (leaves/pericarps) with an organic solvent

!width="300" bgcolor=DodgerBlue|'''Composition action'''

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WARNER LAMBERT(2002)

|bgcolor=LightCyan|Organic compound

|bgcolor=LightCyan|Benzopyran compounds

|bgcolor=LightCyan|Rapidly metabolizes, and causes reduced cardiovascular effects as compared to other known potassium channel openers

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LG HOUSEHOLD & HEALTH CARE(2001)

|bgcolor=LightCyan|Natural extracts

|bgcolor=LightCyan|Sophora flavescens extract (alkaloids & flavonoids, luteolin-7-glucose and cytosine) Hinokitiol (Taiwan hinoki oil, Aomori, Western Red Cedar oil) and Nicotinamide (Vitamin B complex)

!width="300" bgcolor=DodgerBlue|'''Composition action'''

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N/A(2000)

|bgcolor=LightCyan|Peptides

|bgcolor=LightCyan|Testosterone blocker or vascular toner (Flutamide, cyproterone acetate, spironolactone, progesterone, or analogs or derivatives) and minoxidil mixed along with non-retinoid penetration enhance and sunscreen

|bgcolor=LightCyan|Inhibits 5.alpha.-reductase activity (block DHT) and increase blood flow on the scalp

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L'OREAL(2000)

|bgcolor=LightCyan|Peptides

|bgcolor=LightCyan|Prostaglandin (polyunsaturated fatty acids) EP-2, EP-3 EP-4 receptor agonist with Minoxidil, 2,4-diaminopyrimidine 3-oxide, and Aminexil, cyclic AMP

|bgcolor=LightCyan|Minoxidil (designed to mimic nitric oxide's effects) grows hair via prostaglandin-H synthase stimulation. EP-3 and EP-4 are expressed in anagen hair follicles which induce a reduction in the level of cAMP

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COLOMER GROUP(1999)

|bgcolor=LightCyan|Natural extract

|bgcolor=LightCyan|Hop extract (oil contains terpenes and humulene), Rosemary extract (hydroalcohol), Swertia extract (glycol with a swertiamarin), Silanodiol salicylate (biologically active silicon compound)

!width="300" bgcolor=DodgerBlue|'''Composition action'''

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|bgcolor=LightCyan|Organic compound

|bgcolor=LightCyan|(2-substituted oxyphenyl) alkanamide derivative and its salt

|bgcolor=LightCyan|Mechanism of action has not been made clear, having excellent hair follicle activating action and regrowth promoting effect

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|bgcolor=LightCyan|Peptides

|bgcolor=LightCyan|Metalloprotease (MMP-9) inhibitor (thiol or a hydroxamate) other than chelating calcium ions

!width="300" bgcolor=DodgerBlue|'''Composition action'''

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Unilever(2005)

|bgcolor=LightCyan|Natural extract and organic compound

|bgcolor=LightCyan|Polyamine (putrescine, spermine or spermidine) analogs and/or derivatives; DFMO; N-acetyl cysteines; neutralized salts of a non-hydroxy C2-C40 dicarboxylic acids, preferably malonate salts; and mixtures thereof.

|bgcolor=LightCyan|Decreasing sebum production and/or pore size

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KAO COPR.(2004)

|bgcolor=LightCyan|Natural extract and organic compound

|bgcolor=LightCyan|Avocado oil (Butyl esters of fatty acids)

|bgcolor=LightCyan|Reduce sebum of the hair and scalp

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Unilever(1982)

|bgcolor=LightCyan|organic compound

|bgcolor=LightCyan |Biotin antagonist or a salt thereof

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|bgcolor=LightCyan|2-substituted oxyphenyl alkanamide derivative having excellent hair growth effect.

|bgcolor=LightCyan|1

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|bgcolor=LightCyan|Thyromimetic compounds, and its role in treating hair loss

|bgcolor=LightCyan|2

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|bgcolor=LightCyan|Saw Palmetto berry extract, pumpkin seed extract, sitosterol and quercetin for the treatment and prevention of the biologically detrimental effects of DHT

|bgcolor=LightCyan|3

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|bgcolor=LightCyan|4-cycloalkoxy benzonitriles and its use as androgen receptor modulators

|bgcolor=LightCyan|4

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|bgcolor=LightCyan|Supercritical fluid isolate of Saw Palmetto, Sperol for inhibition of 5-.alpha.-reductase activity

|bgcolor=LightCyan|5

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|bgcolor=LightCyan|New class of quinolin-2-ones and chromen-2-ones andtheir use as androgen receptor antagonists

|bgcolor=LightCyan|6

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|bgcolor=LightCyan|Antiandrogen oligonucleotides usable for the treatment of dermatological androgen-related disorders

|bgcolor=LightCyan|7

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|bgcolor=LightCyan|Bradykinin antagonists for stimulating or inducing hair growth and/or arresting hair loss

|bgcolor=LightCyan|8

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|bgcolor=LightCyan|Extract from walnut leaves and/or pericarps as 5 alpha -reductase inhibitor

|bgcolor=LightCyan|9

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|bgcolor=LightCyan|Stimulating hair growth using benzopyrans

|bgcolor=LightCyan|10

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|bgcolor=LightCyan|Sophora flavescens extract, Coicis semen extract, clove extract, etc for promoting hair growth, function of cell activity and dilating peripheral blood vessels.

|bgcolor=LightCyan|11

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|bgcolor=LightCyan|Compositions to prevent or reduce hair loss

|bgcolor=LightCyan|12

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|bgcolor=LightCyan|Prostaglandin EP-3 receptor antagonists for reducing hair loss

|bgcolor=LightCyan|13

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|bgcolor=LightCyan|Synergic effect arising from the interaction of active ingredients, consisting of three plant extracts and a synthetic organosilicic compound for prevent hair loss and stimulate hair growth

|bgcolor=LightCyan|14

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|bgcolor=LightCyan|Metalloprotease inhibitors to induce and/or stimulate the growth

|bgcolor=LightCyan|15

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|bgcolor=LightCyan|Method of decreasing sebum production and pore size

|bgcolor=LightCyan|16

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|bgcolor=LightCyan|Method for reducing sebum on the hair and skin

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