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Alopecia - Hair Loss

649 bytes added, 12:10, 28 April 2006
Beta-sitosterol reduce inflammation on scalp
|- style="height:20px"
|bgcolor=PlumLightCyan|US20060009427
WARNER LAMBERT(2004)[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060009427%22.PGNR.&OS=DN/20060009427&RS=DN/20060009427]
|bgcolor=PlumLightCyan|Organic compound|bgcolor=PlumLightCyan|New class of 4-cycloalkoxy benzonitrile derivatives and salts|bgcolor=PlumLightCyan|Acts as androgen receptor modulators and blocks formation of DHT.
|- style="height:20px"
|bgcolor=PlumLightCyan|US20050085467
WARNER LAMBERT(2004)
[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050085467%22.PGNR.&OS=DN/20050085467&RS=DN/20050085467]
|bgcolor=PlumLightCyan|Organic compound|bgcolor=PlumLightCyan|New class of 6-sulfonamido-quinolin-2-one and 6-sulfonamido-2-oxo-chromene derivatives.|bgcolor=PlumLightCyan|The compounds inhibit, or decrease, activation of androgen receptor by androgens.
|- style="height:20px"
|bgcolor=PlumLightCyan|US20050118282
APHIOS Corp (2003)
[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050118282%22.PGNR.&OS=DN/20050118282&RS=DN/20050118282]
|bgcolor=PlumLightCyan|Natural extracts|bgcolor=PlumLightCyan|Supercritical fluid isolate of Saw Palmetto and Sperol (Serenoa repens berry) and their analogs or derivatives.|bgcolor=PlumLightCyan|Modulates androgenic activity by inhibiting 5.alpha.-reductase activity.
|- style="height:20px"
|bgcolor=PlumLightCyan|US20060009429
Fundacion Pablo Cassara (2003)
[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060009429%22.PGNR.&OS=DN/20060009429&RS=DN/20060009429]
|bgcolor=PlumLightCyan|Nucleotide|bgcolor=PlumLightCyan|Pharmacologically active oligonucleotides (encompass both DNA and S-DNA bond)|bgcolor=PlumLightCyan|Oligonucleotides inhibit androgen receptor (AR) expression at very low concentrations in skin and hair follicle
|- style="height:20px"
|bgcolor=PlumLightCyan|US20030007941
PFIZER INC (2001)
[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220030007941%22.PGNR.&OS=DN/20030007941&RS=DN/20030007941]
|bgcolor=PlumLightCyan|Organic compound|bgcolor=PlumLightCyan|Thyromimetic compounds (structurally similar to thyronine) with finasteride, or cyproterone acetate |bgcolor=PlumLightCyan|Activates thyroid hormone receptors in hair follicle which in turn promote elasticisation of follicle walls and hair follicle
|- style="height:20px"
|bgcolor=PlumLightCyan|US20030073616
N/A (1995)
[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220030073616%22.PGNR.&OS=DN/20030073616&RS=DN/20030073616]
|bgcolor=PlumLightCyan|Peptides/nucleic acid|bgcolor=PlumLightCyan|Bradykinin antagonist (peptide of plasma origin from kininogen precursor-kallikrein)|bgcolor=PlumLightCyan|Inhibit synthesis of bradykinin receptors or compounds by binding to B2 receptor
|- style="height:20px"
|bgcolor=Plum|EP0279010
KAO Corp (1987)
[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=EP0279010&F=0]
|bgcolor=PlumLightCyan|Natural extracts|bgcolor=PlumLightCyan|Walnut extract (leaves/pericarps) with an organic solvent|bgcolor=PlumLightCyan|Blocks formation of DHT
|}
!width="300" bgcolor=DodgerBlue|'''Composition action'''
|- style="height:100px"
|bgcolor=PlumLightCyan|US20040157856
WARNER LAMBERT(2002)
[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040157856%22.PGNR.&OS=DN/20040157856&RS=DN/20040157856]
|bgcolor=PlumLightCyan|Organic compound|bgcolor=PlumLightCyan|Benzopyran compounds|bgcolor=PlumLightCyan|Rapidly metabolizes, and causes reduced cardiovascular effects as compared to other known potassium channel openers
|- style="height:100px"
|bgcolor=PlumLightCyan|US20050053572
LG HOUSEHOLD & HEALTH CARE(2001)
[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050053572%22.PGNR.&OS=DN/20050053572&RS=DN/20050053572]
|bgcolor=PlumLightCyan|Natural extracts|bgcolor=PlumLightCyan|Sophora flavescens extract (alkaloids & flavonoids, luteolin-7-glucose and cytosine) Hinokitiol (Taiwan hinoki oil, Aomori, Western Red Cedar oil) and Nicotinamide (Vitamin B complex)|bgcolor=PlumLightCyan|Promotes function of cell activity and dilates blood vessels
|}
!width="300" bgcolor=DodgerBlue|'''Composition action'''
|- style="height:100px"
|bgcolor=PlumLightCyan|US20060052405
N/A(2000)
[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060052405%22.PGNR.&OS=DN/20060052405&RS=DN/20060052405]
|bgcolor=PlumLightCyan|Peptides|bgcolor=PlumLightCyan|Testosterone blocker or vascular toner (Flutamide, cyproterone acetate, spironolactone, progesterone, or analogs or derivatives) and minoxidil mixed along with non-retinoid penetration enhance and sunscreen|bgcolor=PlumLightCyan|Inhibits 5.alpha.-reductase activity (block DHT) and increase blood flow on the scalp
|- style="height:100px"
|bgcolor=PlumLightCyan|US20050123577
L'OREAL(2000)
[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050123577%22.PGNR.&OS=DN/20050123577&RS=DN/20050123577]
|bgcolor=PlumLightCyan|Peptides|bgcolor=PlumLightCyan|Prostaglandin (polyunsaturated fatty acids) EP-2, EP-3 EP-4 receptor agonist with Minoxidil, 2,4-diaminopyrimidine 3-oxide, and Aminexil, cyclic AMP|bgcolor=PlumLightCyan|Minoxidil (designed to mimic nitric oxide's effects) grows hair via prostaglandin-H synthase stimulation. EP-3 and EP-4 are expressed in anagen hair follicles which induce a reduction in the level of cAMP
|- style="height:100px"
|bgcolor=PlumLightCyan|US6447762
COLOMER GROUP(1999)
[http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6447762.PN.&OS=PN/6447762&RS=PN/6447762]
|bgcolor=PlumLightCyan|Natural extract|bgcolor=PlumLightCyan|Hop extract (oil contains terpenes and humulene), Rosemary extract (hydroalcohol), Swertia extract (glycol with a swertiamarin), Silanodiol salicylate (biologically active silicon compound)
|bgcolor=Plum|Inhibits activity of 5-alpha-reductase, protects follicular cell membranes by neutralizing action of oxidation reaction in tissues, stimulates hair follicles and blood circulation to the hair root, supplies oxygen and nutrients to base of follicle, retains humidity, avoids dehydration of scalp
|}
!width="300" bgcolor=DodgerBlue|'''Composition action'''
|- style="height:100px"
|bgcolor=PlumLightCyan|US20020052498
SHISEIDO(1999)
[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220020052498%22.PGNR.&OS=DN/20020052498&RS=DN/20020052498]
|bgcolor=PlumLightCyan|Organic compound|bgcolor=PlumLightCyan|(2-substituted oxyphenyl) alkanamide derivative and its salt|bgcolor=PlumLightCyan|Mechanism of action has not been made clear, having excellent hair follicle activating action and regrowth promoting effect
|- style="height:100px"
|bgcolor=PlumLightCyan|US20040071647
L'OREAL(1998)
[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040071647%22.PGNR.&OS=DN/20040071647&RS=DN/20040071647]
|bgcolor=PlumLightCyan|Peptides|bgcolor=PlumLightCyan|Metalloprotease (MMP-9) inhibitor (thiol or a hydroxamate) other than chelating calcium ions|bgcolor=PlumLightCyan|Reducing the expression of MMPs (Metalloproteases) in the scalp - slow down or inhibit the degradation of the perifollicular matrix (extracellular matrix surround the hair follicle)
|}
!width="300" bgcolor=DodgerBlue|'''Composition action'''
|- style="height:100px"
|bgcolor=PlumLightCyan|US20050277699
Unilever(2005)
[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050277699%22.PGNR.&OS=DN/20050277699&RS=DN/20050277699]
|bgcolor=PlumLightCyan|Natural extract and organic compound|bgcolor=PlumLightCyan|Polyamine (putrescine, spermine or spermidine) analogs and/or derivatives; DFMO; N-acetyl cysteines; neutralized salts of a non-hydroxy C2-C40 dicarboxylic acids, preferably malonate salts; and mixtures thereof. |bgcolor=PlumLightCyan|Decreasing sebum production and/or pore size
|- style="height:100px"
|bgcolor=PlumLightCyan|US20050244362
KAO COPR.(2004)
[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050244362%22.PGNR.&OS=DN/20050244362&RS=DN/20050244362]
|bgcolor=PlumLightCyan|Natural extract and organic compound|bgcolor=PlumLightCyan|Avocado oil (Butyl esters of fatty acids) |bgcolor=Plum|bgcolor=PlumLightCyan|Reduce sebum of the hair and scalp
|- style="height:100px"
|bgcolor=PlumLightCyan|US4529587
Unilever(1982)
[http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4529587.PN.&OS=PN/4529587&RS=PN/4529587]
|bgcolor=PlumLightCyan|organic compound|bgcolor=PlumLightCyan |Biotin antagonist or a salt thereof |bgcolor=PlumLightCyan|Decrease activity of the enzyme acetyl-SCoA-carboxylase and hence reduce lipid synthesis in sebaceous glands so that less sebum is produced
|}
!width="75" bgcolor=DodgerBlue|'''Natural extract + Organic comp'''
|- style="height:10px"
|bgcolor=PlumLightCyan|2005 |bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|.... |bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|UNILEVER (1)
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|bgcolor=PlumLightCyan|2004 |bgcolor=PlumLightCyan|WARNER (1)|bgcolor=PlumLightCyan|BLOTECH (1) |bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|KAO (1)
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|bgcolor=PlumLightCyan|2003|bgcolor=PlumLightCyan|WARNER (1)|bgcolor=PlumLightCyan|APHIOS (1) |bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|FUNDIACION (1)|bgcolor=PlumLightCyan|....
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|bgcolor=PlumLightCyan|2002|bgcolor=PlumLightCyan|WARNER (1)|bgcolor=PlumLightCyan|.... |bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|....
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|bgcolor=PlumLightCyan|2001|bgcolor=PlumLightCyan |PFIZER (1)|bgcolor=PlumLightCyan|LG HEALTH-CARE (1) |bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|....
|-
|bgcolor=PlumLightCyan|2000|bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|.... |bgcolor=PlumLightCyan|L’OREAL (1) / N/A (1)|bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|....
|-
|bgcolor=PlumLightCyan|1999|bgcolor=PlumLightCyan|SHISEDIO (1)|bgcolor=PlumLightCyan|COLOMER (1) |bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|....
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|bgcolor=PlumLightCyan|1998|bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|.... |bgcolor=PlumLightCyan|L’OREAL (1)|bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|....
|-
|bgcolor=PlumLightCyan|1995|bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|.... |bgcolor=PlumLightCyan|N/A (1)|bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|....
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|bgcolor=PlumLightCyan|1987|bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|KAO (1)|bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|....
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|bgcolor=PlumLightCyan|1982|bgcolor=PlumLightCyan|UNILEVER (1)|bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|....|bgcolor=PlumLightCyan|....
|}
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