Changes
!width="300" bgcolor=DodgerBlue|'''Composition action'''
|- style="height:100px"
|bgcolor=Plum|US20020052498
SHISEIDO(1999)
[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220020052498%22.PGNR.&OS=DN/20020052498&RS=DN/20020052498]
|bgcolor=Plum|Organic compound|bgcolor=Plum|(2-substituted oxyphenyl) alkanamide derivative and its salt|bgcolor=Plum|Mechanism of action has not been made clear, having excellent hair follicle activating action and regrowth promoting effect
|- style="height:100px"
|bgcolor=Plum|US20040071647
L'OREAL(1998)
[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040071647%22.PGNR.&OS=DN/20040071647&RS=DN/20040071647]
|bgcolor=Plum|Peptides|bgcolor=Plum|Metalloprotease (MMP-9) inhibitor (thiol or a hydroxamate) other than chelating calcium ions|bgcolor=Plum|Reducing the expression of MMPs (Metalloproteases) in the scalp - slow down or inhibit the degradation of the perifollicular matrix (extracellular matrix surround the hair follicle)
|}
!width="300" bgcolor=DodgerBlue|'''Composition action'''
|- style="height:100px"
|bgcolor=Plum|US20050277699
Unilever(2005)
[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050277699%22.PGNR.&OS=DN/20050277699&RS=DN/20050277699]
|bgcolor=Plum|Natural extract and organic compound|bgcolor=Plum|Polyamine (putrescine, spermine or spermidine) analogs and/or derivatives; DFMO; N-acetyl cysteines; neutralized salts of a non-hydroxy C2-C40 dicarboxylic acids, preferably malonate salts; and mixtures thereof. |bgcolor=Plum|Decreasing sebum production and/or pore size
|- style="height:100px"
|bgcolor=Plum|US20050244362
KAO COPR.(2004)
[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050244362%22.PGNR.&OS=DN/20050244362&RS=DN/20050244362]
|bgcolor=Plum|Natural extract and organic compound|bgcolor=Plum|Avocado oil (Butyl esters of fatty acids) |bgcolor=Plum|bgcolor=Plum|Reduce sebum of the hair and scalp
|- style="height:100px"
|bgcolor=Plum|US4529587
Unilever(1982)
[http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4529587.PN.&OS=PN/4529587&RS=PN/4529587]
|bgcolor=Plum|organic compound|bgcolor=Plum|Biotin antagonist or a salt thereof |bgcolor=Plum|Decrease activity of the enzyme acetyl-SCoA-carboxylase and hence reduce lipid synthesis in sebaceous glands so that less sebum is produced
|}
