Changes
* DHT causes increase in hair loss and gradual miniaturization of the follicle, which eventually dies resulting hair loss
=== Functions of Anti-androgen ===[http://www.revivogen.com/revivogen/work.html]
[[Image:Andogen1.jpg|thumb|center|500px|Functions of Anti-androgen]]
* Minoxidil sulfate (MS) appears to be the active metabolite responsible for hair growth stimulation.
=== Functions of Monoxidil ===[http://www.nurseminerva.co.uk/diagrams.htm#Diagram%201]
[[Image:minoxidil1.jpg|thumb|center|500px|Functions of Monoxidil]]
* Combination of Minoxidil + Anti-androgen (double action) composition for effective treatment of Male-Pattern Baldness
=== Functions of (Anti-androgen + Minoxidil) ===[http://www.revivogen.com/revivogen/work.html]and [http://www.xandrox.net/articles/article01.htm]
[[Image:Doubleaction1.jpg|thumb|center|500px|Functions of (Anti-androgen + Minoxidil)]]
* Growth and differentiation of the matrix cells are under the influence of substances produced by cells of the dermal papilla.
=== Functions of Hair matrix cell activator ===[http://www.ijdb.ehu.es/fullaccess/fulltext.04023/ft163.pdf]
[[Image:Hair matrix.jpg|thumb|center|500px|Functions of Hair matrix cell activator ]]
|Metalloprotease (MMP-9) inhibitor (thiol or a hydroxamate) other than chelating calcium ions
|Reducing the expression of MMPs (Metalloproteases) in the scalp - slow down or inhibit the degradation of the perifollicular matrix (extracellular matrix surround the hair follicle)
|}
== Sebum Production Inhibitor ==
* The inhibitor blocks the excessive sebum production produces greasy effect on hair and scalp and also responsible for thinning and loosing of hair.
=== Functions of Sebum Production Inhibitor ===
[[http://en.wikipedia.org/wiki/Image:HairFollicle.jpg]]
[[Image:Sebum1.jpg|thumb|center|500px|Functions of Sebum Production Inhibitor]]
=== IP map for Sebum Production Inhibitor === {| border="1" cellpadding="3"!width="100"|'''Pat/Pub#'''!width="75"|'''Nature'''!width="300"|'''Composition''' !width="300"|'''Composition action'''|- style="height:100px" |US20050277699Unilever(2005)[[Imagehttp:Sebum2//appft1.jpguspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050277699%22.PGNR.&OS=DN/20050277699&RS=DN/20050277699] |thumbNatural extract and organic compound|centerPolyamine (putrescine, spermine or spermidine) analogs and/or derivatives; DFMO; N-acetyl cysteines; neutralized salts of a non-hydroxy C2-C40 dicarboxylic acids, preferably malonate salts; and mixtures thereof. |700pxDecreasing sebum production and/or pore size |Table listing different functions - style="height:100px" |US20050244362KAO COPR.(2004)[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050244362%22.PGNR.&OS=DN/20050244362&RS=DN/20050244362] |Natural extract and organic compound|Avocado oil (Butyl esters of Sebum Production Inhibitor]fatty acids) |Reduce sebum of the hair and scalp|- style="height:100px" |US4529587Unilever(1982)[http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4529587.PN.&OS=PN/4529587&RS=PN/4529587]|organic compound|Biotin antagonist or a salt thereof |Decrease activity of the enzyme acetyl-SCoA-carboxylase and hence reduce lipid synthesis in sebaceous glands so that less sebum is produced |}
== Composition nature matrix ==
{| border="1" cellpadding="11"
!width="50"|'''Year'''
!width="75"|'''Organic Compound'''
!width="75"|'''Natural extracts'''
!width="75"|'''Peptides'''
!width="75"|'''Nucleotides'''
!width="75"|'''Natural extract + Organic comp'''
|-
|2005
|....
|....
|....
|....
|UNILEVER (1)
|-
|2004
|WARNER (1)
|BLOTECH (1)
|....
|....
|KAO (1)
|-
|2003
|WARNER (1)
|APHIOS (1)
|....
|FUNDIACION (1)
|....
|-
|2002
|WARNER (1)
|....
|....
|....
|....
|-
|2001
|PFIZER (1)
|LG HEALTH-CARE (1)
|....
|....
|....
|-
|2000
|....
|....
|L’OREAL (1) / N/A (1)
|....
|....
|-
|1999
|SHISEDIO (1)
|COLOMER (1)
|....
|....
|....
|-
|1998
|....
|....
|L’OREAL (1)
|....
|....
|-
|1995
|....
|....
|N/A (1)
|....
|....
|-
|1987
|....
|KAO (1)
|....
|....
|....
|-
|1982
|UNILEVER (1)
|....
|....
|....
|....
|}
== Focus on different aspects ==
