Changes
/* Structure-Activity Relationships(SARs) */
{{TOCrightEx}}
== Rationale ==
* "Medication for men plagued by hair loss has become a topic of interest in Japan since a drug company began marketing it at the end of last year." March 5th, 2006 – [http://stophair.setupmyblog.com/?p=55Source] * "An increasing number of companies are apparently turning the Chinese fear of a bald spot into big bucks with some doing so well they are branching out into other countries." February 16, 2006 – [http://stophair.setupmyblog.com/Source] * "There is something in the air, or should we say in the hair, these days. Scientific research into hair loss remedies has never been more active or more exciting." June 7, 2006 - [http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=109&STORY=/www/story/06-07-2005/0003821470&EDATE=Source]<br><br> == Alopecia IPMap == [http://www.dolcera.com/client/ds94x0s90akq9d7xb402fm/hairloss_map.htm Dolcera IPMap for Alopecia]<br>
== Introduction ==
* Hair is a complex and delicate part of the body.
* Keeping it healthy and beautiful is a challenge.
* Hair grows everywhere on the body with the exception of the lips, eyelids, the palms of the hands and soles of the feet.
* Hair is basically a form of skin.
* Hair is made up of a protein called keratin.
* Each shaft of hair is made of two or three inter-twined layers of keratin which grow from a follicle beneath the skin.
* Hair Structure - [http://www.pg.com/science/haircare/hair_twh_12.htmSource]* Hair Cycle - [http://www.follicle.com/hair-structure-life-cycle.htmlSource] [[Image:Hairbasics.jpg|thumb|center|400px|Structure of Hair root and Hair bulb]]
=== What causes hair loss? ===
* Decreased Decrease in growth of the hair * Increased Increase in shedding of the hair * Breakage of hairs hair
* Conversion of thick terminal hairs to thin vellus hairs
[[Image:Facts.jpg|thumb|right|250px|Survey results from Japan]]
Both men and women lose hair for similar reasons. Hair loss in men is often more dramatic, and follows a specific pattern of loss, one of which has been termed “Male Pattern Baldness" or "Androgenetic Alopecia".
=== Types of alopecia===
* Alopecia Mucinosa: A type of alopecia which results in scaley patches.
* Androgenetic Alopecia (AGA): Also known as male pattern baldness. It is a thinning of the hair to an almost transparent state, in both men or women. It is thought to be a hereditary form of hair loss.
* Traction Alopecia: Traction alopecia is usually due to excessive pulling or tension on hair shafts as a result of certain hair styles. It is seen more often in women, particularly those of East Indian and Afro-Caribbean origin. Hair loss depends on the way the hair is being pulled. Prolonged traction alopecia can stop new hair follicles from developing and lead leads to permanent hair loss.* Anagen Effluvium: This hair loss is generally caused by chemicals such as those used to treat cancer. Initially it causes patchy hair loss, which often then becomes leads to total hair loss. The good news is that when you stop using these chemicals the hair normally grows back (usually about 6 months later). Other drugs also can cause hair loss. Many medicines used to treat even common diseases can cause hair loss.
* Scarring Alopecia: A form of alopecia which leaves scarring on the area of hair loss.
* Telogen Effluvium: A form of hair loss where more than normal amounts numbers of hair fall out. There is a general 'thinning' of the hair. Unlike some other hair and scalp conditions, it is temporary and the hair growth usually recovers. ([http://www.alopeciaonline.org.uk/about/types.asp Source])
=== Androgenetic alopecia ===
== Major players ==
[[Image:players.jpg|thumb|left|400px500px|Assignees with more than 20 patents ]][[Image:players1.jpg|thumb|center|400px500px|Assignees with fewer than 20 patents ]]<br>
* '''Active assignees'''
[[Image:Active.jpg|thumb|center|500px|Active Assignees]]
== Taxonomy ==
[[Image:Alopecia toxonomy.jpg|thumb|center|800px]]
== Interactive Taxonomy ==
''Use the mouse(click and drag/scroll up or down/click on nodes) to explore nodes in the detailed taxonomy'' <br>
''Click on the red arrow on the side of a node name to view the content for that particular node in the dashboard''
<mm>[[Map12.mm]]</mm>
== Treatment Approaches==
Composition of treatment for causes are identified and categorized as follows:
* Anti-androgens(Finasteride) [http://www.emedicine.com/DERM/topic21.htm source]* Vasodilators (Minoxidil)[http://www.emedicine.com/DERM/topic21.htm source]
* Double action (Anti-androgen + Vasodilator)
* Hair matrix cells activator
!width="400" bgcolor=DodgerBlue|'''Composition action'''
|- style="height:20px"
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060009430%22.PGNR.&OS=DN/20060009430&RS=DN/20060009430 [US20060009430]]
BLOTECH (2004)
|bgcolor=LightCyan|Natural extracts
|bgcolor=LightCyan|Organic compound
|bgcolor=LightCyan|New class of 4-cycloalkoxy benzonitrile derivatives and salts
|bgcolor=LightCyan|Acts as androgen receptor modulators modulator and blocks formation of DHT.
|- style="height:20px"
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050085467%22.PGNR.&OS=DN/20050085467&RS=DN/20050085467 US20050085467]
|bgcolor=LightCyan|Peptides/nucleic acid
|bgcolor=LightCyan|Bradykinin antagonist (peptide of plasma origin from kininogen precursor-kallikrein)
|bgcolor=LightCyan|Inhibit Inhibits synthesis of bradykinin receptors or compounds by binding to B2 receptor
|- style="height:20px"
|bgcolor=LightCyan|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=EP0279010&F=0 EP0279010]
'''What causes hair loss?'''
* A thick network of tiny veins and arteries lines line the outer wall of the follicle. Blood pumps through the bulb and hair via this network.
* DHT accumulates in the hair follicles and roots, constricting the blood supply of oxygen and nutrients to the hair roots; which is also seen to possibly contribute towards hair loss.
'''How does Minoxidil treat hair loss?'''
* Minoxidal Minoxidil is applied to the scalp topically, where it dilates blood vessels in the scalp and sustains the hair follicles for longer period of time.* Minoxidil is thought to have a direct mitogenic effect on epidermal cells, as has been observed both in vitro and in vivo. Though the mechanism of its action for causing cell proliferation is not very clear, minoxidil is thought to prevent intracellular calcium entry. Calcium normally enhances epidermal growth factors to inhibit hair growth, and Minoxidil by getting converted to minoxidil sulfate acts as a potassium channel agonist and enhances potassium ion permeability to prevent calcium ions from entering into cells.([http://www.hairtransplantadvice.com/medical-hair-restoration.php sourceSource])
* Minoxidil sulfate (MS) appears to be the active metabolite responsible for hair growth stimulation.
'''What is the problem with using only Anti-androgen therapy?'''
* Anti-androgen is not effective in addressing the issue of vasocontriction around hair follicles due to sebum oil build up.
* Anti-androgen only prevent prevents binding of DHT to androgen receptors. However, the effects of improper oxygen and nutrient supply to the brain due to vasocontriction still remains and gradually causes hair loss.
'''What is the problem with using only Vasodilator (or Minoxidil only) therapy?'''
* Vasodilator or Minoxidil-based products are generally not effective in stopping hair loss as vasodilators (or Minoxidil) does do not block the harmful effects of DHT in the scalp and hair follicles. * Vasodilators or Minoxidil simply dilates dilate blood vessels in the scalp. However, the harmful DHT is still being gets produced in the body and still getting into , enters the scalp and hair follicles and causing eventual hair loss.
'''How is the combination of Anti-androgens and Vasodilator (or Minoxidil) effective?'''
* Anti-androgens target the problem of DHT binding to androgen receptors and prevents follicle miniaturization.
* Vasodilators like Minoxidil causes cause vasodilation and therefore improves improve supply of oxygen and nutrients to the hair follicle and roots.
* Combination therapy therefore proves to be much more effective than individual therapy.
==== Functions of (Anti-androgen + Vasodilators) ==== [http://www.revivogen.com/revivogen/work.html Anti-androgen ]and [http://www.xandrox.net/articles/article01.htm Minoxidil]
[[Image:Doubleaction1.jpg|thumb|center|500px|Functions of (Anti-androgen + Vasodilators)]]
N/A(2000)
|bgcolor=LightCyan|Peptides
|bgcolor=LightCyan|Testosterone blocker or vascular toner (Flutamide, cyproterone acetate, spironolactone, progesterone, or analogs or derivatives) and minoxidil mixed along with non-retinoid penetration enhance enhancer and sunscreen
|bgcolor=LightCyan|Inhibits 5.alpha.-reductase activity (block DHT) and increase blood flow on the scalp
|- style="height:100px"
* Matrix activator allows activation of hair matrix cells and therefore follicle stimulation leading to hair growth.
==== Functions of Hair matrix cell activator ==== [http://www.ijdb.ehu.es/fullaccess/fulltext.04023/ft163.pdf Hair matrix cell activator]
[[Image:Hair matrix.jpg|thumb|center|500px|Functions of Hair matrix cell activator ]]
!width="200" bgcolor=DodgerBlue|'''Composition'''
!width="600" bgcolor=DodgerBlue|'''Composition action'''
|- style="height:100px50px"
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220020052498%22.PGNR.&OS=DN/20020052498&RS=DN/20020052498 US20020052498]
SHISEIDO(1999)
|bgcolor=LightCyan|(2-substituted oxyphenyl) alkanamide derivative and its salt
|bgcolor=LightCyan|Mechanism of action has not been made clear, having excellent hair follicle activating action and regrowth promoting effect
|- style="height:100px50px"
|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040071647%22.PGNR.&OS=DN/20040071647&RS=DN/20040071647 US20040071647]
L'OREAL(1998)
|bgcolor=LightCyan|Peptides
|bgcolor=LightCyan|Metalloprotease (MMP-9) inhibitor (thiol or a hydroxamate) other than chelating calcium ions
|bgcolor=LightCyan|Reducing the expression of MMPs (Metalloproteases) in the scalp - slow slows down or inhibit inhibits the degradation of the perifollicular matrix (extracellular matrix surround surrounding the hair follicle)
|}
== Technology mapping based on patents anlyzed analyzed ==
=== IPMap: Composition nature matrix ===
|bgcolor=LightCyan|....
|}
=== Focus of patents ===
=== Technology focus===
[[Image:Technologyfocus2.jpg|thumb|center|700px|Technology focus]]
=== Distribution of patents ===
==== Target species ====
[[Image:Species.jpg|thumb|center|700px|Target species]]
|}
== Signaling Pathway == [[List of patents]] ====== Pathways and linkages ==
=== Pathways associated with hair matrix cell activation===
=== Pathways associated with Anti Androgen===
==== Players of Wnt WNT inhibition Pathway ==== [[Image:wnt.jpg|thumb|right|200 px|Wnt inhibition]]
{| border="1" cellpadding="15", style="#008080"
!width="150" bgcolor=DodgerBlue|'''Patent no.'''
|bgcolor=LightCyan|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO03011287&F=0 WO2003011287]
|bgcolor=LightCyan|Pyrazolon derivatives
|bgcolor=LightCyan|GSK3, βß-catenin
|-
|bgcolor=LightCyan|[http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6924141.PN.&OS=PN/6924141&RS=PN/6924141 US6924141]
|bgcolor=LightCyan|Lithium chloride, Wnt3/4/ 7
|bgcolor=LightCyan|βß-catenin, GSK3, Wnt
|-
|bgcolor=LightCyan|[http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6706685.PN.&OS=PN/6706685&RS=PN/6706685 US6706685]
|bgcolor=LightCyan|Peptide sequence
|bgcolor=LightCyan|βß-catenin
|-
|bgcolor=LightCyan|[http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6683048.PN.&OS=PN/6683048&RS=PN/6683048 US6683048]
|bgcolor=LightCyan|Peptide sequence
|bgcolor=LightCyan|αa-catenin, βß-catenin
|-
|bgcolor=LightCyan|[http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6677116.PN.&OS=PN/6677116&RS=PN/6677116 US6677116]
|bgcolor=LightCyan|Peptide sequence LXXLL
|bgcolor=LightCyan|βß-catenin
|-
|bgcolor=LightCyan|[http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6303576.PN.&OS=PN/6303576&RS=PN/6303576 US6303576]
|bgcolor=LightCyan|Peptide sequence LXXLL
|bgcolor=LightCyan|βß-catenin
|}
'''Pyrazole'''
* '''Pyrazole''' (C3H4N2) refers both to the class of simple aromatic ring organic compounds of the heterocyclic series characterized by a 5-membered ring structure composed of three carbon atoms and two nitrogen atoms in adjacent positions and to the unsubstituted parent compound. Being so composed and having pharmacological effects on humans, they are classified as alkaloids although they are not known to occur in nature.
* Pyrazoles are produced synthetically through the reaction of αa,βß-unsaturated aldehydes with hydrazine and subsequent dehydrogenation
[[Image:pyrazole1.jpg|thumb|center|500px|Pyrazole (C3H4N2)]]
* Pyrazoles are used for their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, tranquilizing, muscle relaxing, psychoanaleptic, anticonvulsant, monoamineoxidase inhibiting, antidiabetic and antibacterial activities.
=== Pathway associated with anti-androgen ===
* Dihydrotestosterone
** Formed by peripheral conversion of testosterone by 5-alpha reductase
** Binds to androgen receptor on susceptible hair follicles
* Hormone-receptor complex activates genes responsible for gradual transformation of large terminal follicles to miniaturized (progressive diminution of hair shaft diameter and length in response to systemic androgens) follicles
[[Image:5-alpha-reductase inhibition.jpeg|center|500 px]]
==== Structure-Activity Relationships(SARs) ====
[[Image:SAR_map.gif|center|600px720px]]
=== Pathway associated with Minoxidil (vasodilators) ===
Minoxidil is a well know drug used for the treatment of alopecia. A co-relation between Sesquiterpene lactone (Helenalin) produced from Arnica montana and Minoxidil is illustrated in the figure below. Arnica montana, a Vasodilator, acts on the NO/cGMP Pathway through T-cells, B-cells and epithelial cells & abrogates kappa B-driven gene expression.
[[image:vasodiator-rev.jpg|800 px|center]]
== Conclusions Alopecia IPMap ==* Hair loss medication is a very active area of research and intellectual property development[http://www.* One of the most promising areas of development is the area of Anti-androgensdolcera.* The top companies are Merck, L’Oreal and Smithklinecom/client/d8r3/hairloss_map.htm Dolcera IPMap for Alopecia]
== Patent activity in China =====Treatment approaches==={|border="2" cellspacing="0" cellpadding="4" width="100%"|align = "center"|'''Any hints for research?Treatment approach'''* Are there any combinations |align = "center"|'''Patent number'''|align = "center"|'''Priority year'''|align = "center"|'''Assignee/Inventor'''|-|rowspan = "7"|Vasodilators|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN200510107497.8&leixin=fmzl&title=治疗瘀血阻滞型脱发的中草药汤剂及制备方法&ipc=A61K36/804(2006.01)I could developCN1772105]|2005|叶明伟|-|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=CN1772139&F=0 CN1772139]|2005|王亚杰|-|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN03139861.8&leixin=fmzl&title=一种可用于治疗脱发、白发的天然中草药提取组合物及应用&ipc=A61K35/78 CN1569080]|2003|谈汝标|-|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN02155404.8&leixin=fmzl&title=毛囊激活液&ipc=A61K35/78 CN1506103]|2002|赵章光|-|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN01127395.X&leixin=fmzl&title=一种止脱生发药物及其制备方法&ipc=A61K35/78 CN1403100]|2001|范希田|-|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN96116925.7&leixin=fmzl&title=免洗养发生发香波&ipc=C11D3/48 CN1165181]|1996|殷国健|-|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN88103853.9&leixin=fmzl&title=一种通络生发香波&ipc=A61K7/06 CN1031022]|1988|天津市轻工业化学研究所|-|Hair matrix activator|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN02111941.4&leixin=fmzl&title=一种含中西药复方的育发剂&ipc=A61K7/06 CN1463693]|2002|朱静建|-|Anti-androgen <nowiki>+</nowiki> Vasodilator|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN96109964.X&leixin=fmzl&title=一种治疗脂溢性脱发的高效低副作用外用药物&ipc=A61K35/78 CN1150043]|1996|梅晓春|-|}
{|border="2" cellspacing="0" cellpadding="4" width="100%" align="left"|align = "center"|'''What’s my competition up to?Patent number'''|align = "center"|'''Patent title'''|align = "center"|'''Treatment approach'''|align = "center"|'''Composition nature'''|align = "center"|'''Composition'''|align = "center"|'''Composition action'''|-|align = "justify"|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN200510107497.8&leixin=fmzl&title=治疗瘀血阻滞型脱发的中草药汤剂及制备方法&ipc=A61K36/804(2006.01)I CN1772105]<br>YE MINGWEI (CN)<br>叶明伟 (2005)|align = "justify"|Chinese herbal medicine decoction for treating blood stasis obstruction type alopecia and its prepn<br>治疗瘀血阻滞型脱发的中草药汤剂及制备方法|align = "justify"|Vasodilators|align = "justify"|Herbal extract|align = "justify"|Astragalus root, prepared rhizome of rehmannia, white peony root, angelica, peach kernel and sufflower|align = "justify"|Promote blood circulation|-|align = "justify"|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=CN1772139&F=0 CN1772139<br>]WANG YAJIE (CN)<br>王亚杰 2005|align = "justify"|Alopecia areata treating medicine<br>一种治疗斑秃的药物|align = "justify"|Vasodilators|align = "justify"|Herbal extract|align = "justify"|Pinellia tuber, fleeceflower root, arborvitae seed, chickení s gizzard membrane, prepared rhizome of rehmannia, Poris cocos, Codonopsis pilosula, etc|align = "justify"|Promote blood circulation|-|align = "justify"|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN03139861.8&leixin=fmzl&title=一种可用于治疗脱发、白发的天然中草药提取组合物及应用&ipc=A61K35/78 CN1569080]<br>TAN RUBIAO (CN)<br>谈汝标 2003|align = "justify"|Natural Chinese herb composition for treating alopecia and leucotrichia and its application<br>一种可用于治疗脱发、白发的天然中草药提取组合物及应用|align = "justify"|Vasodilators|align = "justify"|Herbal extract|align = "justify"|Ginger, Cinnamomum cassia, myrrh, clove, mace nutmeg, Loranthus mulberry mistletoe, rhizoma dioscoreae, ligustrum japonicum, drynaria, fleece-flower root, and black sesame seeds|align = "justify"|Enhances the hair growth and healthier hairs|-|align = "justify"|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN02111941.4&leixin=fmzl&title=一种含中西药复方的育发剂&ipc=A61K7/06 CN1463693]<br>朱静建 2002|Hair growing preparation containing compound of Chinese medicine and Western medicine<br>一种含中西药复方的育发剂|align = "justify"|Hair matrix activator|Mixture of Herbal extracts and western medicine|align = "justify"|Persimmon leaf, oriental arbor-vitae leaf, ginseng leaf, yellow qi, fruit of the glossy privet, polygonum multiflorum, Kudzu root, dry ginger; Plus：Minoxidil, Vitamins and derivative, cystine, serine, leucine.|align = "justify"|Better and faster hair growth|-|align = "justify"|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN02155404.8&leixin=fmzl&title=毛囊激活液&ipc=A61K35/78 CN1506103]<br>赵章光2002|align = "justify"|Hair follice activating liquid<br>毛囊激活液|align = "justify"|Vasodilators|align = "justify"|Herbal extract|align = "justify"|Ginseng, twists the stock blue, the licorice, the Sophora flavescens and hot peppers|align = "justify"|Activates the hair-follicle and enhances the hair growth.|-|align = "justify"|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN01127395.X&leixin=fmzl&title=一种止脱生发药物及其制备方法&ipc=A61K35/78 CN1403100]<br>范希田 2001|align = "justify"|Trichogen and its prepn<br>一种止脱生发药物及其制备方法|align = "justify"|Vasodilators|align = "justify"|Herbal extract|align = "justify"|Ginseng, ganoderma lucidum, Chinese rhubarb, polygonum multiflorum, Chinese prickly ash, ginger, grass seed|align = "justify"|Promote blood circulation and enhance hair growth|-|align = "justify"|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN96116925.7&leixin=fmzl&title=免洗养发生发香波&ipc=C11D3/48 CN1165181]<br>殷国健 1996|Washing free shampoo for nourishing and growing hair<br>免洗养发生发香波|align = "justify"|Vasodilator|Vitamin composition|align = "justify"|Vitamin P (Bioflavonoids), Vitamin B15, Vitamin B2, nicotinic acid, bromo—geramineum|align = "justify"|Stimulate hair growth|-|align = "justify"|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN96109964.X&leixin=fmzl&title=一种治疗脂溢性脱发的高效低副作用外用药物&ipc=A61K35/78 CN1150043]<br>梅晓春 1996|Efficient low-side effect external use medicine for curing seborrheic baldness<br>一种治疗脂溢性脱发的高效低副作用外用药物|align = "justify"|Anti-androgen <nowiki>+</nowiki> Vasodilator|Mixture of Herbal extracts and organic compounds|align = "justify"|Polygonum multiflorum, Ligustrum lucidum, Morus alba, Rehmannia glutinosa, Eclipta prostrata, Saliva miltiorrhiza, Carthamus tinctorius, Cnidium monnieri, Sophora flavescens, Dictamnus dasycarpus, Kochia scoparia, and antioxidants|align = "justify"|Inhibit the excess secretion of the sebaceous glands, increase the blood circulation on scalp and enhance the hair growth|-|align = "justify"|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN88103853.9&leixin=fmzl&title=一种通络生发香波&ipc=A61K7/06 CN1031022]<br>天津市轻工业化学研究所 1988|Channel-stimulating and hair-growing hair shampoo<br>一种通络生发香波|align = "justify"|Vasodilators|Herbal extract <nowiki>+</nowiki> detergent|align = "justify"|<font color="#454545">Herbal extracts, Penetration media, Detergents.</font>|align = "justify"|Increases the blood circulation under the scalp, reduces the hair los|-|}<br clear="all">
==<span style="color:#C41E3A">Like this report?</span>==<p align="center"> '''How do I play defense?This is only a sample report with brief analysis'''<br>* What should my blocking'''Dolcera can provide a comprehensive report customized to your needs'''</reactive strategies be?p>{|border="2" cellspacing="0" cellpadding="4" align="center" "|style="background:lightgrey" align = "center" colspan = "3"|'''[mailto:info@dolcera.com <span style="color:#0047AB">Buy the customized Alopecia report from Dolcera</span>]''' |-| align = "center"| [http://www.dolcera.com/website_prod/services/ip-patent-analytics-services Patent Analytics Services]|align = "center"| [http://www.dolcera.com/website_prod/services/business-research-services Market Research Services]|align = "center"| [http://www.dolcera.com/website_prod/tools/patent-dashboard Purchase Patent Dashboard]|-|align = "center"| [http://www.dolcera.com/website_prod/services/ip-patent-analytics-services/patent-search/patent-landscapes Patent Landscape Services]|align = "center"| [http://www.dolcera.com/website_prod/research-processes Dolcera Processes]|align = "center"| [http://www.dolcera.com/website_prod/industries Industry Focus]|-|align = "center"| [http://www.dolcera.com/website_prod/services/ip-patent-analytics-services/patent-search/patent-landscapes Patent Search Services]|align = "center"| [http://www.dolcera.com/website_prod/services/ip-patent-analytics-services/alerts-and-updates Patent Alerting Services]|align = "center"| [http://www.dolcera.com/website_prod/tools Dolcera Tools]|-|}<br> == Conclusions ==* Hair loss medication is a very active area of research and intellectual property development.* One of the most promising areas of development is the area of Anti-androgens.* The top companies are Merck, L’Oreal and Smithkline. ==Contact Dolcera== {| style="border:1px solid #AAA; background:#E9E9E9" align="center"|-! style="background:lightgrey" | Contact Dolcera|-| '''Email''': [mailto:info@dolcera.com info@dolcera.com]|-| '''Phone''': +1-650-269-7952|}
