* The figure below illustrates the phosphorylation mechanism of serine and threonine by ATP.
[[image:GSK3_phosphorylation.jpg|300 px|thumb|Phosphorylation mechanism]]
* The common phosphorylation procedure through ATP to ADP conversion we can’t stop.
* Thus we have to target on the Oxygen atom I the Phosphorous group, marked in the red circles in the figure above. As oxygen is a Lewis acid with strong electron donating capacity, so usually a strong electron pair acceptor can easily bind to oxygen atom and preventing phosphorylation
== Conclusions ==