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__NOTOC__===1. [[#Intellectual Property (IP) Services|Intellectual Property(IP) Services]]=Sample of the RNAi Database Dashboard=====2[http://client. [[#Business and Information Research Services|Business and Information Research Services]]dolcera.com/dashboard/dashboard.html?workfile_id======3. [[#Dolcera Technology Platform|Dolcera Technology Platform587 RNAi Database]]===

== Intellectual Property (IP) Services Overview=={| style="border:1px solid #AAA; background:#E9E9E9;width:100%" align="center"|-! style="background:lightgrey;width:50%" valign = "top" | ===Life Sciences and Chemistry===! style="background:lightgrey;width:50%" valign = "top" | ===Technology===|-| valign = "top" |=== Landscape reports ===* [[Alopecia - Hair Loss]] | ([http://www.youtube.com/watch?v=jAIoyKuKQ6o Video])* [[Inflammation and cardiovascular drugs]]* [[Hormone Sensitive Lipase]]* [[RNA Interference]]* [[RNAi Database sample wiki]]* [[Choline Bitartarate]]* [[Non-wovens]]* [[Pressure sensitive adhesives]] | ([http://www.youtube.com/watch?v=plP3TzjYsiQ Video])* [[Ureteral Stent]]* [[Smart miniature drug delivery systems]]* [[Silicone Hydrogel contact lens]]* [[Bio-fuels database sample wiki]]* [[SC Johnson]]| valign = "top" |

=== Landscape Reports ===* [[Hybrid Electric Vehicle Battery System]]* Image:rnai1.jpg|250 px|right|thumb|RNA Interference [[Supply Chain RFID Applications]]* [[Insurance sector]]* [[CDMA Basics]]* [[Quality of Service on CDMA platforms]]* [[OLED http://www.sciencemag.org/feature/e- Organic Light Emitting Diodemarket/prodlink/qiasihp.jpg Source]]* [[Carbon Nanotubes (CNT)]]* [[Metallic and Ceramic construction materials]]* [[Transactional memory]]* [[Invalidation Search on a patent in the semiconductors space]]|-| valign = "top" |

=== Licensing ===* '''RNA interference (RNAi)''', is a technique in which exogenous, double-stranded RNAs (dsRNAs) that are complimentary to known mRNAs, are introduced into a cell to specifically destroy that particular mRNA, thereby diminishing or abolishing gene expression. * [[Environment Friendly Technology This technology considerably bolsters functional genomics to Replace Cadmium Coatingsaid in the identification of novel genes involved in disease processes and thus can be used for medicament and for delivery as therapeutics. [http://www.bmj.com/cgi/content/full/328/7450/1245 Source]* RNA interference was known by other names, including post transcriptional gene silencing and quelling. [http://en.wikipedia.org/wiki/RNA_interference Source]

===STN Search ReportsEffector RNA molecules===* [[Markush Search Report]]RNAi pathways are guided by small RNAs that include

=== Dashboard ===* [http'''SiRNA://client.dolcera.com/dashboard/dashboard.html?workfilegroup_id=10 Alopecia areata dashboard - live] ''' ** Small interfering RNA ([[Alopecia Areata Dashboard Screenshots|Screenshots only]]siRNA) * [http://www, sometimes known as short interfering RNA or silencing RNA, is a class of 20-25 nucleotide-long double-stranded RNA molecules.dolcera.com/ipmapdemo/stent_model.swf Stent dashboard]* [http://wwwSiRNAs can also be exogenously (artificially) introduced into cells by various transfection methods to bring about the specific knockdown of a gene of interest.dolcera.com/website/demos/dna/main.html Sequence dashboard]* [[Legal Updates Demo|Legal updates dashboard]]* [[http://clienten.dolcerawikipedia.comorg/dashboardwiki/dashboard.html?workfile_id=587 RNAi DashboardSiRNA Source]]| valign = "top" |

=== Dashboard ==='''miRNA:'''* [http://clientmicroRNAs (miRNA) are single-stranded RNA molecules of about 21–23 nucleotides in length, which regulate gene expression.dolcera.com/dashboard/dashboard.html?workfilegroup_id=27 Automotive dashboard - live]** [[Automotive Dashboard Screenshots|Screenshots only]]miRNAs are encoded by genes from whose DNA they are transcribed but miRNAs are not translated into protein (non-coding RNA); instead each primary transcript (a pri-miRNA) is processed into a short stem-loop structure called a pre-miRNA and finally into a functional miRNA. * [http://clientMature miRNA molecules are partially complementary to one or more messenger RNA (mRNA) molecules, and their main function is to down-regulate gene expression.dolcera.com/dashboard/dashboard.html?workfile_id=54 WiMAX dashboard - live] ** [[WiMAX Dashboard Screenshots|Screenshots only]]* [http://wwwen.dolcerawikipedia.comorg/ipmapdemowiki/rfid_model.swf RFID dashboardMicroRNA Source]|-| valign = "top" |

=== Prior Art / Invalidation / FTO Search ==='''shRNA:'''* A small hairpin RNA or short hairpin RNA (shRNA) is a sequence of RNA that makes a tight hairpin turn that can be used to silence gene expression via RNA interference. shRNA uses a vector introduced into cells and utilizes the U6 promoter to ensure that the shRNA is always expressed. This vector is usually passed on to daughter cells, allowing the gene silencing to be inherited. The shRNA hairpin structure is cleaved by the cellular machinery into siRNA, which is then bound to the RNA-induced silencing complex (RISC). This complex binds to and cleaves mRNAs which match the siRNA that is bound to it. [http://dolceraen.comwikipedia.org/clientwiki/d8r3/hairloss_map.htm Alopecia/Hair loss IPMapSmall_hairpin_RNA Source]* [[Markush Structure Search Sample]]==== Study: In re Bilski Impact ====* [[In re Bilski Impact assessed from US PAIR Information]]| valign = "top" |

=== Prior Art / Invalidation / FTO Search ==='''Others:'''* [http://wwwIn addition to miRNAs and siRNAs, other innate RNAi effectors have been identified.dolcera** One class of these is the Piwi-interacting RNAs (piRNAs).com/ipmapdemo/satellite_antenna/ipmappiRNAs seem to be uniquely expressed in the mammalian germline, particularly in the testes. The functional role of piRNAs is currently unclear, but a role in spermatogenesis is likely.html Satellite Antenna IPMap]* * A number of other small RNAs associated with RNAi have been identified in different species, including trans-activating siRNAs (tasiRNAs), studied in plants and nematodes, and small scan RNAs (ScnRNAs), found in Tetrahymena. [http://wwwarjournals.dolceraannualreviews.comorg/ipmapdemodoi/rfidabs/ipmap10.html RFID IPMap1146/annurev.genom.8.080706.092424?cookieSet=1&journalCode=genom Source]* ==Cellular Mechanism== '''The RNA interference pathway:''' Long double-stranded RNA (dsRNA) or small hairpin RNA (shRNA) is processed by Dicer to form a small interfering RNA (siRNA), which associates with RNA-induced silencing protein complex (RISC) and mediates target sequence specificity for subsequent mRNA cleavage leading to gene silencing. [[Image:mech1.jpg|450 px|center|thumb|RNA Interference mechanism [http://www.dolceraarthritis-research.com/ipmapdemocontent/multimodal_appsfigures/ipmapar1168-1.html Multimodal Applications IPMapjpg Source]]]* ==Cancer specific Targets==[[Image:genes1.jpg|700px|center|thumb|'''Cancer specific Targets [http://wwwjournals.dolceraprous.com/ipmapdemojournals/Invalidation_US4825448servlet/xmlxsl/pk_journals.htm Invalidation Claim Map Samplexml_summaryn_pr?p_JournalId=3&p_RefId=985937 '''Source]]]|-|}=='''Intellectual property'''== === Search Strategy=== Effective search strategy ensures that all key words covering the technology are adequately covered. IPC class limitations help in removing the unwanted patents.

{|border="2" cellspacing= Business and Information Research Services "0" cellpadding="4" width="100%"{| stylealign = "center" bgcolor ="border:1px solid #AAA; background:CCFFCC"|'''S.No.'''|align = "center" bgcolor = "#E9E9E9;width:100%CCFFCC" |'''Concept'''|align="center"bgcolor = "#CCFFCC"|'''Search scope'''|align = "center" bgcolor = "#CCFFCC"|'''Query'''|align = "center" bgcolor = "#CCFFCC"|'''No. of Hits'''

! style|align ="background:lightgreycenter" valignbgcolor =top width=50%"#CCFFCC"| '''1'''|align ===Life Sciences and Chemistry==="center"|RNAi! style|align ="background:lightgreycenter" valign|Claims,Title, Abstract|align =top width=50%"center"|(siRNA<nowiki>*</nowiki>1 OR (short ADJ1 interfering ADJ1 RNA<nowiki>*</nowiki>1) OR (short ADJ1 interfering ADJ1 nucleic ADJ1 acid<nowiki>*</nowiki>1) OR (short ADJ1 interfering ADJ1 NA<nowiki>*</nowiki>1) OR siNA OR siNAs OR (si ADJ1 RNA<nowiki>*</nowiki>1) OR (Small adj1 interfering adj1 RNA<nowiki>*</nowiki>)OR miRNA or (microRNA<nowiki>*</nowiki> or micro adj1 RNA<nowiki>*</nowiki>)OR shRNA or (small adj1 hairpin adj1 RNA<nowiki>*</nowiki>)OR piRNA or (Piwi adj1 interacting adj1 RNA<nowiki>*</nowiki>)OR tasiRNAs or (trans adj1 activating adj1 siRNA<nowiki>*</nowiki>) OR ScnRNAs or (small adj1 scan adj1 RNA<nowiki>*</nowiki>)OR RNAi or(RNA adj1 interference))|align ===Technology==="center"|12729

| valignalign =top "center" bgcolor = "#CCFFCC"|'''2'''* [[Diabetes products and services]]* [[Osteoporosis]]* [[Oral Diabetes Drugs]]* [[Ureteral Stent]]* [[Premium Coffee Consumers Market Segmentation|Premium Coffee - Market Positioning]]align = "center"|IPC* [[Dolcera's Poster on Industrial Biotechnology|Industrial biotechnology]]* [[OTC products for acne treatment]]* [[Botox - from Medical Procedure to Household Word]]align = "center"| | valignalign =top "center"|a61k or c12q or c12n or c07k or c07h* [[4G wireless technology developments]]* [[HDTV in the US]]* [http://www.dolcera.com/ipmapdemo/innovation_explorer/innovation_explorer.html Household robotics Innovation Explorer]* [[Web video]]* [[OLED Mobile Phones Market Research and Analysis Report]] | ([http://www.viddler.com/explore/dolcera/videos/6/ Video])* [[Virtualization]]* [[Cloud Computing]]* [[Estimation of liquid carrying vehicles in USA]]* [[A market study on Hybrid vehicles and the concept of V2G]]align = "center"|1688146

! style|align ="background:lightgreycenter" valignbgcolor =top colspan"#CCFFCC"|'''3'''|align ="center"|'''BCL2'''|align = "center"|Full Patent Spec|align = "center"|(Bcl2 OR (Bcell ADJ1 CLL) OR (Bcell ADJ1 Lymphoma2 ) OR DKFZp781P2092) and Current IPC-R a61k or c12q or c12n or c07k or c07h|align = "center"|3890|-|align = "center" bgcolor = "#CCFFCC" rowspan = "2 "|'''4'''|align = "center" rowspan = "2"|BCL2 <nowiki>+</nowiki> RNAi <nowiki>+</nowiki>IPC|align = "center" rowspan = "2"| |align = "center" rowspan = "2"|'''1 AND 3'''|align = "center" rowspan = "2"|'''633<br>(293 unique records)'''

== Dolcera Technology Platform Interactive Taxonomy=={| style="border:1px solid #AAA; background:#E9E9E9;width:100%" align="center"|-| align = "top" |==== IP and Products dashboard ====* [http://client.dolcera.com/dashboard/dashboard.html?workfilegroup_id=10 Alopecia areata dashboard] * [http://www.dolcera.com/ipmapdemo/stent_model.swf Stent dashboard]* [[Legal Updates Demo|Legal updates dashboard]]* [http://client.dolcera.com/dashboard/dashboard.html?workfile_id=54 4G wireless product and patent dashboard]

==== Patent-pathway mapping ====* [[Inflammation and cardiovascular drugs#Interactive signaling pathways Grouping specific elements into more general categories is conceptually easier and cleaner than is entertaining hundreds of specific elements separately. We categorize the information from analyzed patents|Patentand scientific literate into four levels of taxonomy which allow both “bird’s-pathway mapping]]==== Sequence dashboard ====* [http://www.dolcera.com/website/demos/dna/maineye view” and “in-depth views” of scientific technologies.html Sequence dashboard]

==== Innovation explorer ====* [http[Image://wwwtax21.dolcera.com/ipmapdemo/innovation_explorer/innovation_explorer.html Household robotics innovation explorerjpg|800px|center|thumb| '''Interactive Taxonomy''']==== KPort ====* [http://dolcera.com/website/demos/kport/main.html Collaboration Portal]

=='''Top Players and Patenting Activity'''== [[Image:bcl2.jpg|800px|center|thumb| '''Bcl-2''']] ==RNAi Database Dashboard== RNAi database dashboard: *Categorize and organize large sets of product, patent, and scientific literature*Analyze client’s competitive position and that of key competitors*Identify licensing opportunities*Make build-vs.-buy decisions in new product areas*Predict product features based on technology and market trends   [[Image:dash1.jpg|}1000px|center|thumb| '''Patent Dashboard''']] ==RNAi Sequence Dashboard== Sequence dashboard allows comparison of siRNA agents extracted from patents and scientific literature to the consensus sequence. Since not all the documents disclose the target sequence, the consensus sequence has to be identified and used for sequence dashboard. For example for Bcl-2, consensus sequence is retrieved from NCBI having seq. id [http://www.ncbi.nlm.nih.gov/nuccore/179370 '''M14745''']. The dashboard also depicts the associated information with RNAi agent on the click of your mouse such as patent number, patent title, length of RNAi agent (siRNA), identity score etc.  [[Image:seq1.jpg|1000px|center|thumb| '''Sequence Dashboard''']] ==Experimental data comparison matrix== Experimental data may be qualitative or quantitative, each being appropriate for different investigations.  Quantitative data was captured from following RNAi experiments for patent focusing on therapeutic application and compared. * % inhibition of target mRNA expression* % encapsulation efficiency * % transfection efficiency * % tumor volume reduction* % cell count reduction

=== [[Technology Support]] '''Patent Focus- Therapeutic Application'''===

{|border="2" cellspacing=<span style"0" cellpadding="color:#C41E3A4">Like any of these sample reports?</span>=width="100%"<p |align="center"> bgcolor = "#C0C0C0" rowspan = "2"|'''These are sample reports with brief analysisSr. No.''' <br>|align = "center" bgcolor = "#C0C0C0" rowspan = "2"|'''Dolcera can provide a comprehensive report customized to your needsPatent/Publication No.'''</p>{|borderalign ="2center" cellspacingbgcolor ="0#FFCC99" cellpaddingcolspan ="42" |'''Target gene'''|align="center" bgcolor = "|style#FF99CC" colspan ="background:lightgrey7" |'''Experimental Details'''|align = "center" colspan bgcolor = "3#99CCFF" rowspan = "2"|'''[mailto:info@dolcera.com <span style="color:#0047AB">Buy the customized report from Dolcera</span>]RANK'''

| align = "center" bgcolor = "#FFCC99"| [http://www.dolcera.com/website_prod/services/ip-patent-analytics'''BCL-services Patent Analytics Services]2'''|align = "center" bgcolor = "#FFCC99"| [http:'''Others'''|align = "center" bgcolor = "#99CC00"|<font color="#000000">'''Test Model'''</font>|align = "center" bgcolor = "#99CC00"|<font color="#000000">'''Inhibition of Target mRNA Expression (%)'''</www.dolcera.comfont>|align = "center" bgcolor = "#99CC00"|<font color="#000000">'''Encapsulation Efficiency'''</website_prodfont>|align = "center" bgcolor = "#99CC00"|<font color="#000000">'''Transfection efficiency Increase (%)'''</servicesfont>|align = "center" bgcolor = "#99CC00"|<font color="#000000">'''Tumor Volume Reduction (%)'''</business-research-services Market Research Services]font>|align = "center" bgcolor = "#99CC00"| [http:<font color="#000000">'''Cell Count Reduction (%)'''</font>|align = "center" bgcolor = "#99CC00"|<font color="#000000">'''Other Remarks'''</www.dolcera.com/website_prod/tools/patent-dashboard Purchase Patent Dashboard]font>

|align = "center" bgcolor = "#C0C0C0"|'''1'''|align = "center"| [http://wwwappft.dolcerauspto.comgov/website_prodnetacgi/services/ip-patent-analyticsnph-servicesParser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070298056%22.PGNR.&OS=DN/patent-search20070298056&RS=DN/patent-landscapes Patent Landscape Services20070298056 US20070298056A1] |align = "center"|Yes|align = "center"| |align = "center"|Human colon cancer (Caco-2) xenografts in nude mice|align = "center"|No|align = "center"|No|align = "center"|No|align = "center"|90.08%<br>Day 25 <br>(Fig 2)|align = "center"|No|align = "center"|No|align = "center" bgcolor = "#99CCFF"|'''1'''|-|align = "center" bgcolor = "#C0C0C0"|'''2'''|align = "center"| [http://wwwappft.dolcerauspto.comgov/website_prodnetacgi/researchnph-processes Dolcera ProcessesParser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080038296%22.PGNR.&OS=DN/20080038296&RS=DN/20080038296 US20080038296A1]|align = "center"|Yes|align = "center"| |align = "center"|In vivo (Mice)|align = "center"|No|align = "center"|No|align = "center"|No|align = "center"|61.29%<br>Day 13<br>(Fig 3)|align = "center"|No|align = "center"|No|align = "center" bgcolor = "#99CCFF"|'''2'''|-|align = "center" bgcolor = "#C0C0C0"|'''3'''|align = "center"| [http://wwwappft.dolcerauspto.comgov/website_prodnetacgi/industries Industry Focusnph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070258952%22.PGNR.&OS=DN/20070258952&RS=DN/20070258952 US20070258952A1]|align = "center"|Yes|align = "center"| |align = "center"|Human pancreatic carcinoma H79 xenografts|align = "center"|No|align = "center"|No|align = "center"|No|align = "center"|49.23%<br>Day 25<br>(Fig 4)|align = "center"|No|align = "center"|No|align = "center" bgcolor = "#99CCFF"|'''2'''

|align = "center" bgcolor = "#C0C0C0"|'''4'''|align = "center"| [http://wwwappft.dolcerauspto.comgov/website_prodnetacgi/services/ipnph-patent-analytics-servicesParser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070172847%22.PGNR.&OS=DN/patent-search20070172847&RS=DN/patent-landscapes Patent Search Services20070172847 US20070172847A1]|align = "center"| [http://www.dolcera.com/website_prod/services/ip-patent-analytics-services/alerts-and-updates Patent Alerting Services]Yes|align = "center"| [http://www|align = "center"|Ramos cells|align = "center"|80%<br>(Fig 4.dolcera.com/website_prod/tools Dolcera Tools]B)|align = "center"|No|align = "center"|No|align = "center"|No|align = "center"|No|align = "center"|No|align = "center" bgcolor = "#99CCFF"|'''2'''

----'''Ranking of patents''' can be done on the basis of focus of the study, experimental data disclosed, effectiveness of RNAi agent, type of model used to test the RNAi agent, etc.  Advantages:*Information disclosure wise sorting available.*Efficiency of different RNAi agent against target gene can be compared.*Different models used to test cell line and the efficiency can also be compared. ===Qualitative Data from Patent Documents===  Experiments yielding qualitative data, mentioned below, can’t be compared but are equally important. We did not miss them! * Gel electrophoresis* Gel blots* Tissue section* Cell staining* RNAi agent construction  {| styleborder="2" cellspacing="0" cellpadding="4" width="100%"|align = "center" bgcolor ="border:1px solid #AAA; background:C0C0C0"|'''Patent/ Publication No.'''|align = "center" bgcolor = "#E9E9E9FFCC99" |'''Gel blots'''|align="center"bgcolor = "#FFCC99"|'''Gel Electrophorosis'''|align = "center" bgcolor = "#FFCC99"|'''Tissue section micrograph'''|align = "center" bgcolor = "#FFCC99"|'''Cell staining micrograph'''|align = "center" bgcolor = "#FFCC99"|'''RNAi Agent Construction'''

! style|align = "center" bgcolor = "#C0C0C0"|'''US20080021205A1'''|align = "center" bgcolor = "#C0C0C0"|Yes|align = "center"|_ _|align = "center"|_ _|align = "center" bgcolor = "#C0C0C0"|Yes|align ="background:lightgreycenter" | Contact Dolcera_ _

! style|align = "center" bgcolor = "#C0C0C0"|'''US20070275465A1'''|align = "center"|_ _|align = "center" bgcolor = "#C0C0C0"|Yes|align = "center"|_ _|align = "center"|_ _|align ="background:lightgreycenter" | Samir Raiyani_ _

|align = "center" bgcolor = "#C0C0C0"| '''EmailWO2007013575A2''': [mailto:info@dolcera.com info@dolcera.com]|align = "center"|_ _|align = "center" bgcolor = "#C0C0C0"|Yes|align = "center" bgcolor = "#C0C0C0"|Yes|align = "center"|_ _|align = "center"|_ _

|align = "center" bgcolor = "#C0C0C0"| '''PhoneUS20070081982A1''': +1|align = "center"|_ _|align = "center"|_ _|align = "center"|_ _|align = "center"|_ _|align = "center" bgcolor = "#C0C0C0"|Yes|-650-269|align = "center" bgcolor = "#C0C0C0"|'''WO2007013575A2'''|align = "center" bgcolor = "#C0C0C0"|Yes|align = "center"|_ _|align = "center" bgcolor = "#C0C0C0"|Yes|align = "center"|_ _|align = "center"|_ _|-7952, +91-40-2355|align = "center" bgcolor = "#C0C0C0"|'''US20050266561A1'''|align = "center"|_ _|align = "center"|_ _|align = "center"|_ _|align = "center"|_ _|align = "center" bgcolor = "#C0C0C0"|Yes|-3493|} *Mathematically incomparable data disclosed in patents