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<p></p> <p><b>New page</b></p><div>AN <br /> 2001:508352 BIOSIS<br /> DN <br /> PREV200100508352<br /> TI <br /> A common hormone-sensitive lipase i6 gene polymorphism is associated<br /> with decreased human adipocyte lipolytic function. <br /> AU <br /> Hoffstedt, Johan [Reprint author]; Arner, Peter; Schalling, Martin;<br /> Pedersen, Nancy L.; Sengul, Selim; Ahlberg, Susanne; Iliadou, Anastasia;<br /> Lavebratt, Catharina<br /> CS <br /> Karolinska Institutet, Huddinge University Hospital, CME, M61, 141 86,<br /> Stockholm, Sweden<br /> johan.hoffstedt@medhs.ki.se<br /> SO <br /> Diabetes, (October, 2001) Vol. 50, No. 10, pp. 2410-2413. print. <br /> CODEN: DIAEAZ. ISSN: 0012-1797. <br /> DT <br /> Article<br /> LA <br /> English<br /> ED <br /> Entered STN: 31 Oct 2001<br /> Last Updated on STN: 23 Feb 2002<br /> AB <br /> Hereditary factors may be involved in the pathogenesis of type 2<br /> diabetes. A polymorphism in the hormone-sensitive lipase (HSL)<br /> gene (HSLi6) is associated with obesity and diabetes, although it is<br /> unknown whether the polymorphism is functional and thereby influences<br /> lipolysis. We genotyped 355 apparently healthy non-obese male and female<br /> subjects for the HSLi6 polymorphism. Allele 5 was found to be the most<br /> common allele (allele frequency 0.57). In 117 of the subjects, we<br /> measured abdominal subcutaneous fat cell lipolysis induced by drugs acting<br /> at various steps in the lipolytic cascade. The lipolysis rate induced by<br /> norepinephrine isoprenaline (acting on beta-adrenoceptors), forskolin<br /> (acting on adenylyl cyclase), and dibutyryl cyclic AMP (acting on HSL)<br /> were all decreased by apprx50% in allele 5 homozygotes, as compared with<br /> noncarriers. Heterozygotes showed an intermediate lipolytic rate. The<br /> difference in lipolysis rate between genotypes was more pronounced in men<br /> than in women. We conclude that allele 5 of the HSLi6 polymorphism is<br /> associated with a marked decrease in the lipolytic rate of abdominal fat<br /> cells. This may in turn contribute to the development of obesity.<br /> CC <br /> Genetics - Human 03508<br /> Metabolism - General metabolism and metabolic pathways 13002<br /> Metabolism - Metabolic disorders 13020<br /> Endocrine - General 17002<br /> IT <br /> Major Concepts<br /> Clinical Endocrinology (Human Medicine, Medical Sciences); Medical<br /> Genetics (Allied Medical Sciences); Metabolism<br /> IT <br /> Diseases<br /> obesity: nutritional disease<br /> Obesity (MeSH)<br /> IT <br /> Diseases<br /> type II diabetes: metabolic disease<br /> Diabetes Mellitus, Non-Insulin-Dependent (MeSH)<br /> IT <br /> Miscellaneous Descriptors<br /> lipolysis<br /> ORGN <br /> Classifier<br /> Hominidae 86215<br /> Super Taxa<br /> Primates; Mammalia; Vertebrata; Chordata; Animalia<br /> Organism Name<br /> human: female, male, patient<br /> Taxa Notes<br /> Animals, Chordates, Humans, Mammals, Primates, Vertebrates<br /> GEN <br /> human HSL gene [human hormone-sensitive lipase gene] (Hominidae)</div>

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