Breast Cancer Trails

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S.No Drug Name Biological Name Developer Current Development Phase Additional Information Start Date Completion Date Source
11 - carcinoembryonic antigen RNA-pulsed DC cancer vaccine Duke University, National Cancer Institute (NCI) I Phase I trial to study the effectiveness of biological therapy in treating patients who have metastatic cancer that has not responded to previous treatment. 2000 2009 Source
12 ETBX-011 AD5 CEA Vaccine Etubics Corporation I/II The purpose of this study is to find out what effects (good and bad) that a cancer vaccine has on you and your cancer. The cancer vaccine is called Ad5 [E1-, E2b-]-CEA(6D)or ETBX-011 and is made by Etubics. This vaccine is based on a virus called an adenovirus but it has been changed to express the protein CEA that is found on some cancer cells. Therefore, the vaccine can tell the immune system to attack cancer cells which make CEA. The investigators are trying to determine whether giving this virus is safe and whether this causes a strong immune system attack on the cancer. ETBX-011 is an investigational drug. - - -
13 cyclophosphamide HER2/neu peptide vaccine Fred Hutchinson Cancer Research Center I/II This phase I/II trial is studying the side effects and best dose of vaccine therapy in treating patients with stage IV breast cancer 2008 2015 Source
14 - Investigational Cancer Vaccine GlaxoSmithKline I This trial will test how safe this vaccine is. It also tests whether its introduction induces an immune response by stimulating the patient?s own immune system to recognize a specific target molecule called HER2, which is overexpressed in many breast cancers. 2003 Ongoing Source
15 - Allogeneic whole epithelial tumor cells, DNP-conjugated and irradiated Hadassah Medical Organization I/II This study is based on the finding that tumor cells that are grown in the laboratory can be modified in such a way that, when injected to the patient, they will stimulate his/her immune response. This approach will be evaluated in patients with colorectal, gastric, ovarian, breast or lung epithelial cancer - - Source
16 - DPX-0908 ImmunoVaccine Technologies, Inc. I To determine the safety and immunogenicity profile of two (2) different doses of the vaccine DPX-0907 to treat breast, ovarian and prostate cancer. - - -
17 - PSMA/PRAME MannKind Corporation I Completed
The present clinical trial is a dose comparison of a multi-component active immunotherapy designed to stimulate an immune reaction to specific tumor associated antigens which are highly expressed on a large number of solid cancers.
2007 2009 Source
18 - aldesleukin, allogeneic large multivalent immunogen breast cancer vaccine Masonic Cancer Center, University of Minnesota II This phase II trial is studying how well giving vaccine therapy together with aldesleukin works in treating women with metastatic breast cancer. 2008 2013 Source
19 - EphA2 Vaccine/ MEDI-543 MedImmune I - - - -
20 - V934/V935 Merck I Completed.
This is a two-part study to test the safety, tolerability, and immune response for V934/V935 vaccine using a new prime-boost regimen in participants with selected solid tumors.
2008 2011 Source
21 - Stimuvax Oncothyreon III Suspended - - -
22 - BCG vaccine, CD80 breast cancer vaccine, sargramostim Providence Cancer Center, Earle A. Chiles Research Institute I Phase I trial to study the effectiveness of vaccines made from breast cancer cells in treating women with metastatic breast cancer. 1996 Ongoing Source
23 Trastuzumab, Cyclophosphamide Allogeneic GM-CSF-secreting breast cancer vaccine Sidney Kimmel Comprehensive Cancer Center, National Cancer Institute (NCI) II Active: This is a feasibility study to examine combination therapy with Trastuzumab (T), Cyclophosphamide (CY), and an allogeneic GM-CSF-secreting whole cell breast cancer vaccine in patients with Stage IV HER-2/neu-overexpressing breast cancer. 2006 2013 Source
24 cyclophosphamide, doxorubicin hydrochloride allogeneic GM-CSF-secreting breast cancer vaccine Sidney Kimmel Comprehensive Cancer Center, National Cancer Institute (NCI) I This phase I trial is studying the side effects and best dose of cyclophosphamide and doxorubicin when given with vaccine therapy in treating women with stage IV breast cancer. 2004 2008 Source
25 - Dendritic Cell Vaccination Southern Cancer Center I The study uses a molecule or particle that is found only on cancer cells and is unique to cancer cells, as it is not detected on normal tissue. The molecule is known as "oncofetal antigen" or OFA. Because OFA is unique to cancer, the investigators feel OFA could be used to educate the patients? own defenses to more effectively fight the cancer on her own, he or she is harboring. 2008 2015 Source
26 - AdhTAP TapImmune Preclinical - - - -
27 - CEA DNA Cancer
Vaccine
Vical/Merck I - - - -
28 cyclophosphamide allogeneic GM-CSF-secreting breast cancer vaccine, recombinant interferon alfa Wiseman Research Initiatives, LLC; National Cancer Institute (NCI) I/II Phase I trial to study the effectiveness of combining vaccine therapy with interferon alfa and cyclophosphamide in treating patients who have stage IV breast cancer. 2004 2010 Source




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