Hormone Sensitive Lipase

Contents

Overview

Hormone Sensitive Lipase (HSL)

Gene: exon/intron organization of the human HSL gene. Exons T and A encode 300 and 43 additional amino acids respectively, located at the N-terminus.
Protein: Linear representation of the amino acid sequence of adipocyte HSL (numbering of the rat sequence).
Domains: N-terminal binding domain, a C-terminal catalytic domain, harbouring the catalytic triad and a regulatory module containing multiple phosphorylation sites. Source
Fates of HSL products

HSL, a drug target for Diabetes and Metabolic Disease

A few points suggesting HSL as a drug tareget for Type 2 Diabetes and Metabolic Disease:

Type 2 Diabetes

Metabolic Disease

Non-patent Literature Search and Analysis

Search Strategy

S.No. Database Key-Words Search Queries No. of Records
Main Terms Alternative Terms
1 BIOSIS
  • Hormone sensitive lipase
  • Type 2 diabetes
  • Hormone-sensitive lipase, Lipase-hormone sensitive, Hormonesensitive lipase, LIPE, HSL, LHS
  • Diabetes, NIDDM, IDDM, T2DM
  • L4 1576 (HORMONE (W) SENSITIVE (2A) LIPASE#) OR HSL OR LHS OR LIPE OR (HORMONESENSITIVE (A) LIPASE#)
  • L5 266641 DIABET? OR NIDDM OR IDDM OR T2DM
  • L6 30 L4 (S) L5
30
2 EMBASE
  • Hormone sensitive lipase
  • Type 2 diabetes
  • Hormone-sensitive lipase, Lipase-hormone sensitive, Hormonesensitive lipase, LIPE, HSL, LHS, L11706, U40001, Q05469
  • Diabetes, NIDDM, IDDM, T2DM
  • L2 1203 (HORMONE (W) SENSITIVE (2A) LIPASE# ) OR (HORMONESENSITIVE (W) LIPASE# ) OR LIPE OR HSL OR LHS OR L11706 OR U40001 OR Q05469
  • L3 258095 DIABET? OR NIDDM OR IDDM OR T2DM
  • L4 32 L2 (S) L3
32
3 DISSABS
  • Hormone sensitive lipase
  • Type 2 diabetes
  • Hormone-sensitive lipase, Lipase-hormone sensitive, Hormonesensitive lipase, LIPE, HSL, LHS
  • Diabetes, NIDDM, IDDM, T2DM
  • L1 131 (HORMONE (W) SENSITIVE (2A) LIPASE ) OR (HORMONESENSITIVE (W) LIPASE ) OR LIPE OR HSL OR LHS
  • L2 6000 DIABET? OR NIDDM OR IDDM OR T2DM
  • L3 5 L1 (S) L2
5
4 MEDLINE
  • Hormone sensitive lipase
  • Type 2 diabetes
  • Hormone-sensitive lipase, Lipase-hormone sensitive, Hormonesensitive lipase, LIPE, HSL, LHS, L11706, U40001, Q05469
  • Diabetes, NIDDM, IDDM, T2DM
  • L1 1331 (HORMONE (W) SENSITIVE (2A) LIPASE ) OR (HORMONESENSITIVE (W) LIPASE ) OR LIPE OR HSL OR LHS OR L11706 OR U40001 OR Q05469
  • L2 286108 DIABET? OR NIDDM OR IDDM OR T2DM
  • L3 29 L1 (S) L2
29
5 BIOTECHNO
  • Hormone sensitive lipase
  • Type 2 diabetes
  • Hormone-sensitive lipase, Lipase-hormone sensitive, Hormonesensitive lipase, LIPE, HSL, LHS, L11706, U40001
  • Diabetes, NIDDM, IDDM, T2DM
  • L1 398 (HORMONE (W) SENSITIVE (2A) LIPASE#) OR (HORMONESENSITIVE (W) LIPASE#) OR LIPE OR HSL OR LHS OR L11706 OR U40001
  • L2 18139 DIABET? OR NIDDM OR IDDM OR T2DM
  • L3 10 L1 (S) L2
10
6 BIOTECHABS
  • Hormone sensitive lipase
  • Type 2 diabetes
  • Hormone-sensitive lipase, Lipase-hormone sensitive, Hormonesensitive lipase, LIPE, HSL, LHS, L11706, U40001, Q05469
  • Diabetes, NIDDM, IDDM, T2DM
  • L1 56 (HORMONE (W) SENSITIVE (2A) LIPASE#) OR (HORMONESENSITIVE (W) LIPASE#) OR LIPE OR HSL OR LHS
  • L2 9716 DIABET? OR NIDDM OR IDDM OR T2DM
  • L3 5 L1 (S) L2
5
7 CONFSCI
  • Hormone sensitive lipase
  • Type 2 diabetes
  • Hormone-sensitive lipase, Lipase-hormone sensitive, Hormonesensitive lipase, LIPE, HSL, LHS
  • Diabetes, NIDDM, IDDM, T2DM
  • L1 90 (HORMONE (W) SENSITIVE (2A) LIPASE#) OR (HORMONESENSITIVE (W) LIPASE#) OR LIPE OR HSL OR LHS
  • L2 1257 DIABET? OR NIDDM OR IDDM OR T2DM
  • L3 0 L1 (S) L2
0
8 NTIS
  • Hormone sensitive lipase
  • Type 2 diabetes
  • Hormone-sensitive lipase, Lipase-hormone sensitive, Hormonesensitive lipase, LIPE, HSL, LHS
  • Diabetes, NIDDM, IDDM, T2DM
  • L1 90 (HORMONE (W) SENSITIVE (2A) LIPASE#) OR (HORMONESENSITIVE (W) LIPASE#) OR LIPE OR HSL OR LHS
  • L2 1257 DIABET? OR NIDDM OR IDDM OR T2DM
  • L3 0 L1 (S) L2
0
  • Total number of records = 106
  • After removing duplicates number of records = 49
  • Total on-targets (after removing duplicates) = 17
  • Accuracy of the query = 35%

Scientific papers on chemical compounds inhibiting or stimulating HSL

Distribution of non-patent articles

the

General scientific studies on HSL found from STN

Patentability Search

Sequence Search and Analysis

Sequence Search Stratagy

S.No. Database Sequence Query Key Words (to restrict unrelated patents) Hits
1 NCBI (Blast)
  • HSL protein
13
2 NCBI (Blast)
  • HSL mRNA
19
3 DGENE (Blast search)
  • HSL protein
  • HSL mRNA
  • diabetes
  • NIDDM
  • IDDM
  • T2DM
61
4 PCTGEN (Blast search)
  • HSL protein
  • HSL mRNA
83
  • In NCBI got 16 relevat patents.
  • In DGENE got 42 relevant patents.
  • In PCTGEN got 16 relevant patents.

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Micropatent Search and Analysis

Final Patent list (with bibliographic information)

Overall IP activity

Overall IP Activity

Key Players (those with more than 2 patents)

Key Players

Other players (those with 1 patent)

Assignee No. of Patents/Publications
Arena Pharmaceuticals 1
Ares Trading 1
Asahi Kasei Pharma Corporation 1
Bionomics 1
Compugen 1
Epiontis 1
Euroscreen 1
Exelixis 1
F. Hoffmann La Roche Ag 1
Five Prime Therapeutics 1
Forschungsverbund Berlin 1
Genetics Iinstitute LLC, Ono Pharmaceuticals 1
GPC Biotech 1
Immunex 1
Linkagene Ltd. 1
Merck & Co 1
Metabolex 1
Micromet AG 1
Nuvelo 1
Ottawa Health Research Institute 1
President & Fellows Of Harvard College 1
Protein Design Labs 1
Regents Of The University Of California 1
Rutgers,The State University Of New Jersey 1
Schering Corporation 1
Sequenom 1
The Buck Institute For Age Research 1
The Regents Of The University Of Michigan 1
University Of Maryland Baltimore 1
Yissum Research Development Company Of The Hebrew University Of Jerusalem 1

Patent Analysis

Patent Distribution (Sample analysis of 25 records only)

Patent Distribution

Dashboard (Sample based on 25 analyzed records)

Interactive Mindmap

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