Tumor necrosis factor is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. The primary role of TNF is in the regulation of immune cells. TNF is also able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNF production has been implicated in a variety of human diseases, as well as cancer Soruce TNF is critically involved in the pathogenesis of several chronic inflammatory diseases. Monoclonal antibodies against TNF are currently used for the treatment of rheumatoid arthritis and Crohn's disease. Dalum et al., 1999
Monoclonal antibodies to tumor necrosis factor alpha (TNF-alpha) and soluble receptor complexes comprising the extramembrane portion of the TNF receptor coupled with the Fc portion of the human IgG1 molecule have been utilized as therapies for severe sepsis and septic shock. Abraham, 2004 A review about TNF-?, based on 78 published articles, using TNF-? antibody is summarized here
Since tumor necrosis factor (TNF) plays an important role in host defense and tumor growth control. Therefore, anti-TNF antibody therapies may increase the risk of serious infections and malignancies. To assess the extent to which anti-TNF antibody therapies may increase the risk of serious infections and malignancies in patients with rheumatoid arthritis a study has been conducted by Bongartz et al., 2006
To capture the Russian patents a 3 way search strategy was built:
Search logic: To first search for all English patents (such as US, WO, EP etc.) with keywords given below and then filter out patents which have Russian family members.
Issue/Publication date: <=20100405
Sr. No. | Search concept | Keywords | Hits |
1 | Keywords based search | ((Antibod* OR (Anti ADJ1 bod*) OR Immunoglobulin*1 OR (Immuno ADJ1 globulin*1) OR MAB OR MABS OR Infliximab OR Remicade OR adalimumab OR Humira OR certolizumab OR pegol OR Cimzia OR golimumab OR Simponi) AND (((Tumour OR Tumor) ADJ2 (necros*2) ADJ2 (factor*1)) OR *TNF OR TNF* OR cachexin OR cachectin)) | 9861 hits |
2 | Key assignee with TNF keywords | Assignee/Applicant: Centocor OR (Johnson ADJ2 Johnson) OR (Mitsubishi ADJ 1Tanabe ADJ1 Pharma*) OR (Xian ADJ1 Janssen) OR (Schering-Plough) OR Abbott OR (BASF ADJ 1Knoll) OR (Cambridge ADJ1 Antibody ADJ1 Technology) OR Medimmune OR (UCB ADJ1 Pharma) AND Keywords in Claims, Tittle and Abstract: TNF* OR (Tumour ADJ2 Necrosis ADJ2 factor*) OR *TNF OR (Tumor ADJ2 Necrosis ADJ2 factor*) |
517 hits |
3 | Key assignee with drug names | Assignee/Applicant: Centocor OR (Johnson ADJ2 Johnson) OR (Mitsubishi ADJ 1Tanabe ADJ1 Pharma*) OR (Xian ADJ1 Janssen) OR (Schering-Plough) OR Abbott OR (BASF ADJ 1Knoll) OR (Cambridge ADJ1 Antibody ADJ1 Technology) OR Medimmune OR (UCB ADJ1 Pharma) AND Keywords in Claims, Tittle and Abstract: Simponi OR Remicade OR Humira OR Cimzia |
10 |
4 | Class based search | ECLA: C07K0014525 OR C07K0014705Q OR C07K0014705R OR C07K0014715B OR C07K001628Q OR C07K001628R OR C07K01624B OR A61K003819A Any classification: C070014525 OR C12N001528 |
293 hits |
Final | 1 OR 2 OR 3 OR 4 | 10190 patents (3772 unique records) (337 records having RU/EA family member) |
Search logic: Micropatent-INPADOC search bibliographic data for 71 countries and legal status for 42. A search strategy based out of keywords and classes was built to search patents having country code RU (Russia) and EA (Eurasia) in Micropatent INPADOC
Sr. No. | Search concept | Keywords | Hits |
1 | Keywords based search | ((Antibod* OR (Anti ADJ1 bod*) OR Immunoglobulin*1 OR (Immuno ADJ1 globulin*1) OR MAB OR MABS OR Infliximab OR Remicade OR adalimumab OR Humira OR certolizumab OR pegol OR Cimzia OR golimumab OR Simponi) AND (((Tumour OR Tumor) ADJ2 (necros*2) ADJ2 (factor*1)) OR *TNF OR TNF* OR cachexin OR cachectin)) | 48 hits |
2 | ECLA classes specific for Anti-TNF antibody | C07K01628Q OR C07501628R OR C07K01624B | 51 hits |
3 | ECLA classes specific for TNF with Antibody keywords | A61k03819A OR C07K014525 OR C07K014705Q OR C07K014705R OR C07K014715B AND ((Antibod* OR (Anti ADJ1 bod*) OR Immunoglobulin*1 OR (Immuno ADJ1 globulin*1) OR MAB OR MABS) OR Infliximab OR Remicade OR adalimumab OR Humira OR certolizumab OR pegol OR Cimzia OR golimumab OR Simponi) | 28 hits |
4 | IPC classes specific for TNF with Antibody keywords | C07014525 OR C12N01528 AND ((Antibod* OR (Anti ADJ1 bod*) OR Immunoglobulin*1 OR (Immuno ADJ1 globulin*1) OR MAB OR MABS) OR Infliximab OR Remicade OR adalimumab OR Humira OR certolizumab OR pegol OR Cimzia OR golimumab OR Simponi) | 5 hits |
5 | 1 OR 2 OR 3 OR 4 | 100 Hits (87 unique records) |
Search Logic: Eurasian patent office allows searching in Russian and Eurasian patent databases. Search was performed based on keywords and class codes as shown below.
Sr. No. | Search concept | Keywords | Hits |
1 | Keywords based search | (Tumor* AND Factor*) OR TNF* | 11 |
2 | Specific class based search | IPC: C07K14/525 OR C12N15/28 | 3 |
3 | Broad class based search | IPC: A61K38/19 OR C07K14/705 OR C07K14/715 OR C07K16/28 OR C07K16/24 | 34 |
Sr. No. | Search concept | Keywords | Hits |
1 | Keywords based search | (Tumor* AND Factor*) OR TNF* | 52 |
2 | Specific class based search | IPC: C07K14/525 OR C12N15/28 | 11 |
3 | Broad class based search | IPC: A61K38/19 OR C07K14/705 OR C07K14/715 OR C07K16/28 OR C07K16/24 | 174 |
S.No | Russian Keywords | English Keywords |
1 | ??? | TNF |
2 | ???-alpha | TNF-alpha |
3 | ?????? ??????? ??????? | tumor necrosis factor |
4 | ????-TNF ????? | anti-TNF alpha |
5 | ????-TNF | anti-TNF |
6 | TNF ????? | TNF alpha |
Sr. No. | Class code | Definition |
1 | A61k03819A | Medicinal preparations containing peptides - Tumor necrosis factor |
2 | C07K014525 | Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof - Tumor necrosis factor (TNF) |
3 | C07K014705Q | Peptides having more than 20 amino acids - NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154 (NGF C07K14/48 , TNF C07K14/525)] [N9706] |
4 | C07K014705R | Peptides having more than 20 amino acids - NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95 |
5 | C07K014715B | Peptides having more than 20 amino acids - for tumor necrosis factor (TNF), for lymphotoxin |
6 | C07K01628Q | Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies - against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154 (against NGF C07K16/22 , against TNF C07K16/24B)] [N9703] [C9705] |
7 | C07501628R | Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies - against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95] [N9702] [C0406] |
8 | C07K01624B | Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies - Tumor Necrosis Factors |
Sr. No. | Class code | Definition |
1 | C07K14/525 | Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof - Tumour necrosis factor (TNF) |
2 | C12N15/28 | Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor - Tumor necrosis factors |
NOTE: Legal status of the Russian patent applications and publications was retrieved from ROSPATENTS wherever available. Legal Status can also be retrieved from STN - INPADOCDB & RUSSIAPAT databases.
Legal Status coverage -Timeline | |
STN- INPADOCDB | 1978 to Present |
STN- RUSSIAPAT | 1994 to Present |
Micropat- INPADOC | 1920 to Present |
Database | Connect hour | Display Record |
STN- INPADOCDB | 232 $ per Hour | 1.24 $ per Record |
STN- RUSSIAPAT | 186 $ per Hour | 2.28 $ per Record |